Mechanochemical‐Induced Swelling–Activation of a Gastric‐Deployable 4D‐Printed Polypill Inspired by Natural Hygromorphic Actuators

Mechanochemical‐Induced Swelling–Activation of a Gastric‐Deployable 4D‐Printed Polypill Inspired by Natural Hygromorphic Actuators

Gastroretentive drug delivery systems can improve adherence in patients with chronic diseases (CDs), but current options lack dose flexibility and involve complex fabrication methods. Inspired by the hygroscopic deformation observed in multilayered pine cone scales, wherein hydration of the outer ac...

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Bibliographic Details
Main Authors: Konstantina Chachlioutaki, Nikolaos Papas, Zisis Chatzis, Orestis L. Katsamenis, Stephanie K. Robinson, Konstantinos Tsongas, Nikolaos Bouropoulos, Dimitrios G. Fatouros, Dimitrios Tzetzis, Christina Karavasili
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Intelligent Systems
Subjects:
4D printings
biomimetics
gastroretentions
mechanochemical deployments
sustained drug releases
swelling activations
Online Access:https://doi.org/10.1002/aisy.202400526
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