Spinal hypermobility accelerates ossification in posterior longitudinal ligaments: insights from an in vivo mouse model

Spinal hypermobility accelerates ossification in posterior longitudinal ligaments: insights from an in vivo mouse model

IntroductionOssification of the posterior longitudinal ligaments (OPLL) is characterized by heterotopic ossification in the posterior longitudinal ligament of spine. Our earlier research found that mechanical stimulation enhances osteogenic differentiation in OPLL-derived ligament cells. Nevertheles...

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Bibliographic Details
Main Authors: Tao Tang, Zhengya Zhu, Zhongyuan He, Fuan Wang, Lin Chen, Jianfeng Li, Hongkun Chen, Jiaxiang Zhou, Jianmin Wang, Shaoyu Liu, Yunfeng Yao, Xizhe Liu, Zhiyu Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Physiology
Subjects:
OPLL
heterotopic ossification
spinal hypermobility
animal models
spinal cord compression
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1561199/full
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