NTRK fusion promotes tumor migration and invasion through epithelial–mesenchymal transition and closely interacts with ECM1 and NOVA1

NTRK fusion promotes tumor migration and invasion through epithelial–mesenchymal transition and closely interacts with ECM1 and NOVA1

Abstract Background The NTRK fusion gene is a rare cancer driver and a typical representative "diamond mutation". Its unique role in tumor progression is highly important for the clinical diagnosis and treatment of patients with tumors. We searched for NTRK fusion-positive patients in our...

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Bibliographic Details
Main Authors: Siqing Zeng, Ke Jiang, Jie Ge, Mimi Tang, Yuqi Wen, Xiaoting Ma, Heli Liu, Xingui Xiong
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Cancer
Subjects:
Cancer
NTRK fusion
EMT
ECM1
TRK inhibitor
Online Access:https://doi.org/10.1186/s12885-024-13271-w
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