Disruption of adaptive immunity does not attenuate disease in the Ndufs4(-/-) model of Leigh syndrome.

Disruption of adaptive immunity does not attenuate disease in the Ndufs4(-/-) model of Leigh syndrome.

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Leigh syndrome (LS) is the most common pediatric presentation of genetic mitochondrial disease and characterized by neurological and metabolic abnormalities. The hallmark of the disease is the presence of progressive, bilateral, symmetric neurodegenerative lesions in the brainstem and/or basal gangl...

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Main Authors: Allison R Hanaford, Asheema Khanna, Vivian Truong, Katerina James, Ryan Liao, Yihan Chen, Michael Mulholland, Ernst-Bernhard Kayser, Kino Watanabe, Erin Shien Hsieh, Philip G Morgan, Surojit Sarkar, Vandana Kalia, Simon C Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0324268
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