Molecular docking approach to identify Bcl-xL inhibitory effect of sesquiterpene coumarins of Ferula species
Background and Aims: Due to the high mortality and morbidity rates associated with cancer, it is crucial to advance research in this area to develop new and effective agents. Natural product chemistry plays a crucial role in identifying potential lead molecules for the treatment of various cancers....
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Istanbul University Press
2025-05-01
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| Series: | İstanbul Journal of Pharmacy |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/E343004922104B1A8CC28B3314CD8261 |
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| author | Fadıl Kaan Kuran Ebru Didem Kuran Mahmut Miski |
| author_facet | Fadıl Kaan Kuran Ebru Didem Kuran Mahmut Miski |
| author_sort | Fadıl Kaan Kuran |
| collection | DOAJ |
| description | Background and Aims: Due to the high mortality and morbidity rates associated with cancer, it is crucial to advance research in this area to develop new and effective agents. Natural product chemistry plays a crucial role in identifying potential lead molecules for the treatment of various cancers. Recently, several studies have demonstrated the selective and potent cytotoxic activity of sesquiterpene coumarins isolated from Ferula species against various cancer cell lines. In this study, we aimed to utilize in silico molecular docking studies to demonstrate the potential of sesquiterpene coumarins as inhibitors of Bcl xL. For this purpose, 35 sesquiterpene coumarins were collected based on previous studies.Methods: Molecular docking studies were conducted to examine the interactions of cytotoxic sesquiter pene coumarins with the active site of the Bcl-xL enzyme, using advanced computational techniques. Additionally, ADME (Absorption, Distribution, Metabolism, and Excretion) studies were performed to predict the pharmacokinetic properties and drug-likeness of sesquiterpene coumarins, ensuring their potential as viable therapeutic agents.Results: As a result of this study, straight-chain sesquiterpene coumarin-derived compounds were more effectively positioned within the active site of the Bcl-xL enzyme and formed hydrogen bonds with amino acids. ADME analysis revealed favourable pharmacokinetic profiles, supporting their potential use in drug development.Conclusion: These findings revealed promising Bcl-xL inhibitory activities of umbelliprene-type sesquiter pene derivatives, which might be a starting point for further structural optimisation to acquire novel compounds exhibiting more potent Bcl-xL inhibitory activity, paving the way for new therapeutic approaches in cancer treatment. |
| format | Article |
| id | doaj-art-97ff54451e45419691e420ae4a13c17c |
| institution | DOAJ |
| issn | 2587-2087 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Journal of Pharmacy |
| spelling | doaj-art-97ff54451e45419691e420ae4a13c17c2025-08-20T02:57:29ZengIstanbul University Pressİstanbul Journal of Pharmacy2587-20872025-05-0155111012210.26650/IstanbulJPharm.2025.1494255123456Molecular docking approach to identify Bcl-xL inhibitory effect of sesquiterpene coumarins of Ferula speciesFadıl Kaan Kuran0https://orcid.org/0000-0003-2793-0577Ebru Didem Kuran1https://orcid.org/0000-0001-5068-0188Mahmut Miski2https://orcid.org/0000-0003-2653-0563İstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeBackground and Aims: Due to the high mortality and morbidity rates associated with cancer, it is crucial to advance research in this area to develop new and effective agents. Natural product chemistry plays a crucial role in identifying potential lead molecules for the treatment of various cancers. Recently, several studies have demonstrated the selective and potent cytotoxic activity of sesquiterpene coumarins isolated from Ferula species against various cancer cell lines. In this study, we aimed to utilize in silico molecular docking studies to demonstrate the potential of sesquiterpene coumarins as inhibitors of Bcl xL. For this purpose, 35 sesquiterpene coumarins were collected based on previous studies.Methods: Molecular docking studies were conducted to examine the interactions of cytotoxic sesquiter pene coumarins with the active site of the Bcl-xL enzyme, using advanced computational techniques. Additionally, ADME (Absorption, Distribution, Metabolism, and Excretion) studies were performed to predict the pharmacokinetic properties and drug-likeness of sesquiterpene coumarins, ensuring their potential as viable therapeutic agents.Results: As a result of this study, straight-chain sesquiterpene coumarin-derived compounds were more effectively positioned within the active site of the Bcl-xL enzyme and formed hydrogen bonds with amino acids. ADME analysis revealed favourable pharmacokinetic profiles, supporting their potential use in drug development.Conclusion: These findings revealed promising Bcl-xL inhibitory activities of umbelliprene-type sesquiter pene derivatives, which might be a starting point for further structural optimisation to acquire novel compounds exhibiting more potent Bcl-xL inhibitory activity, paving the way for new therapeutic approaches in cancer treatment.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/E343004922104B1A8CC28B3314CD8261bcl-xlcancerferulamolecular dockingsesquiterpene coumarins |
| spellingShingle | Fadıl Kaan Kuran Ebru Didem Kuran Mahmut Miski Molecular docking approach to identify Bcl-xL inhibitory effect of sesquiterpene coumarins of Ferula species İstanbul Journal of Pharmacy bcl-xl cancer ferula molecular docking sesquiterpene coumarins |
| title | Molecular docking approach to identify Bcl-xL inhibitory effect of sesquiterpene coumarins of Ferula species |
| title_full | Molecular docking approach to identify Bcl-xL inhibitory effect of sesquiterpene coumarins of Ferula species |
| title_fullStr | Molecular docking approach to identify Bcl-xL inhibitory effect of sesquiterpene coumarins of Ferula species |
| title_full_unstemmed | Molecular docking approach to identify Bcl-xL inhibitory effect of sesquiterpene coumarins of Ferula species |
| title_short | Molecular docking approach to identify Bcl-xL inhibitory effect of sesquiterpene coumarins of Ferula species |
| title_sort | molecular docking approach to identify bcl xl inhibitory effect of sesquiterpene coumarins of ferula species |
| topic | bcl-xl cancer ferula molecular docking sesquiterpene coumarins |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/E343004922104B1A8CC28B3314CD8261 |
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