Research progress of T lymphocytes associated with recurrent spontaneous abortion

Recurrent spontaneous abortion (RSA) is a pregnancy complication with a complex etiology that seriously affects the physical and mental health of women of reproductive age. Although RSA is commonly thought to be caused by an imbalance in maternal-fetal immune tolerance, its specific immune mechanism...

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Main Authors: LIANG Dingyu, YANG Yihua
Format: Article
Language:zho
Published: Editorial Office of Journal of Guangxi Medical University 2024-07-01
Series:Guangxi Yike Daxue xuebao
Subjects:
Online Access:https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.07.021
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author LIANG Dingyu
YANG Yihua
author_facet LIANG Dingyu
YANG Yihua
author_sort LIANG Dingyu
collection DOAJ
description Recurrent spontaneous abortion (RSA) is a pregnancy complication with a complex etiology that seriously affects the physical and mental health of women of reproductive age. Although RSA is commonly thought to be caused by an imbalance in maternal-fetal immune tolerance, its specific immune mechanisms are not yet fully understood. Recent studies have found that an imbalance in the immune microenvironment at the maternal-fetal interface, particularly abnormalities in the function and number of T lymphocytes and their related subsets, are closely related to the occurrence of RSA. This paper aims to review the latest research progress on T lymphocyte changes in RSA, exploring the potential connections between immune cell imbalance in the maternal-fetal interface immune microenvironment and RSA, so as to provide references for basic research and clinical treatment strategies.
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publisher Editorial Office of Journal of Guangxi Medical University
record_format Article
series Guangxi Yike Daxue xuebao
spelling doaj-art-97f8b3f9447d4aa39e5e3eb5a5e53d7c2025-08-20T01:50:22ZzhoEditorial Office of Journal of Guangxi Medical UniversityGuangxi Yike Daxue xuebao1005-930X2024-07-014171094110010.16190/j.cnki.45-1211/r.2024.07.02120240721Research progress of T lymphocytes associated with recurrent spontaneous abortionLIANG Dingyu0YANG Yihua1Guangxi Reproductive Medical Center, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaGuangxi Reproductive Medical Center, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaRecurrent spontaneous abortion (RSA) is a pregnancy complication with a complex etiology that seriously affects the physical and mental health of women of reproductive age. Although RSA is commonly thought to be caused by an imbalance in maternal-fetal immune tolerance, its specific immune mechanisms are not yet fully understood. Recent studies have found that an imbalance in the immune microenvironment at the maternal-fetal interface, particularly abnormalities in the function and number of T lymphocytes and their related subsets, are closely related to the occurrence of RSA. This paper aims to review the latest research progress on T lymphocyte changes in RSA, exploring the potential connections between immune cell imbalance in the maternal-fetal interface immune microenvironment and RSA, so as to provide references for basic research and clinical treatment strategies.https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.07.021recurrent spontaneous abortiont lymphocytesimmunotherapy
spellingShingle LIANG Dingyu
YANG Yihua
Research progress of T lymphocytes associated with recurrent spontaneous abortion
Guangxi Yike Daxue xuebao
recurrent spontaneous abortion
t lymphocytes
immunotherapy
title Research progress of T lymphocytes associated with recurrent spontaneous abortion
title_full Research progress of T lymphocytes associated with recurrent spontaneous abortion
title_fullStr Research progress of T lymphocytes associated with recurrent spontaneous abortion
title_full_unstemmed Research progress of T lymphocytes associated with recurrent spontaneous abortion
title_short Research progress of T lymphocytes associated with recurrent spontaneous abortion
title_sort research progress of t lymphocytes associated with recurrent spontaneous abortion
topic recurrent spontaneous abortion
t lymphocytes
immunotherapy
url https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.07.021
work_keys_str_mv AT liangdingyu researchprogressoftlymphocytesassociatedwithrecurrentspontaneousabortion
AT yangyihua researchprogressoftlymphocytesassociatedwithrecurrentspontaneousabortion