The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review

Porous titanium implants are becoming an important tool in orthopedic clinical applications. This review provides a comprehensive survey of recent advances in porous titanium implants for orthopedic use. First, the review briefly describes the characteristics of bone and the design requirements of o...

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Main Authors: Chunliang Guo, Tao Ding, Yuan Cheng, Jianqing Zheng, Xiule Fang, Zhiyun Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1548675/full
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author Chunliang Guo
Chunliang Guo
Tao Ding
Tao Ding
Yuan Cheng
Jianqing Zheng
Jianqing Zheng
Xiule Fang
Xiule Fang
Zhiyun Feng
Zhiyun Feng
author_facet Chunliang Guo
Chunliang Guo
Tao Ding
Tao Ding
Yuan Cheng
Jianqing Zheng
Jianqing Zheng
Xiule Fang
Xiule Fang
Zhiyun Feng
Zhiyun Feng
author_sort Chunliang Guo
collection DOAJ
description Porous titanium implants are becoming an important tool in orthopedic clinical applications. This review provides a comprehensive survey of recent advances in porous titanium implants for orthopedic use. First, the review briefly describes the characteristics of bone and the design requirements of orthopedic implants. Subsequently, the pore size and structural design of porous titanium alloy materials are presented, then we introduce the application of porous titanium alloy implants in orthopedic clinical practice, including spine surgery, joint surgery, and the treatment of bone tumors. Following that, we describe the surface modifications applied to porous titanium implants to obtain better biological functions. Finally, we discuss incorporating environmental responsive mechanisms into porous titanium alloy materials to achieve additional functionalities.
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publisher Frontiers Media S.A.
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series Frontiers in Bioengineering and Biotechnology
spelling doaj-art-97f7eb339bf74fcaa64b741acaf5fc322025-08-20T02:03:35ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-02-011310.3389/fbioe.2025.15486751548675The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a reviewChunliang Guo0Chunliang Guo1Tao Ding2Tao Ding3Yuan Cheng4Jianqing Zheng5Jianqing Zheng6Xiule Fang7Xiule Fang8Zhiyun Feng9Zhiyun Feng10Wuxi People's Hospital, Wuxi, Jiangsu, ChinaNanjing Medical University, Nanjing, Jiangsu, ChinaWuxi People's Hospital, Wuxi, Jiangsu, ChinaNanjing Medical University, Nanjing, Jiangsu, ChinaWuxi Xishan NJU Institute of Applied Biotechnology, Wuxi, Jiangsu, ChinaWuxi People's Hospital, Wuxi, Jiangsu, ChinaNanjing Medical University, Nanjing, Jiangsu, ChinaWuxi People's Hospital, Wuxi, Jiangsu, ChinaNanjing Medical University, Nanjing, Jiangsu, ChinaWuxi People's Hospital, Wuxi, Jiangsu, ChinaNanjing Medical University, Nanjing, Jiangsu, ChinaPorous titanium implants are becoming an important tool in orthopedic clinical applications. This review provides a comprehensive survey of recent advances in porous titanium implants for orthopedic use. First, the review briefly describes the characteristics of bone and the design requirements of orthopedic implants. Subsequently, the pore size and structural design of porous titanium alloy materials are presented, then we introduce the application of porous titanium alloy implants in orthopedic clinical practice, including spine surgery, joint surgery, and the treatment of bone tumors. Following that, we describe the surface modifications applied to porous titanium implants to obtain better biological functions. Finally, we discuss incorporating environmental responsive mechanisms into porous titanium alloy materials to achieve additional functionalities.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1548675/fulladditive manufacturing3D printingorthopedic implantssurface modificationenvironment-responsivebone tissue engineering
spellingShingle Chunliang Guo
Chunliang Guo
Tao Ding
Tao Ding
Yuan Cheng
Jianqing Zheng
Jianqing Zheng
Xiule Fang
Xiule Fang
Zhiyun Feng
Zhiyun Feng
The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review
Frontiers in Bioengineering and Biotechnology
additive manufacturing
3D printing
orthopedic implants
surface modification
environment-responsive
bone tissue engineering
title The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review
title_full The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review
title_fullStr The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review
title_full_unstemmed The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review
title_short The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review
title_sort rational design biofunctionalization and biological properties of orthopedic porous titanium implants a review
topic additive manufacturing
3D printing
orthopedic implants
surface modification
environment-responsive
bone tissue engineering
url https://www.frontiersin.org/articles/10.3389/fbioe.2025.1548675/full
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