Pre- and post-diagnosis dietary total antioxidant capacity and overall survival in patients with ovarian cancer: a prospective cohort study
Abstract Background The current study aims to investigate the association between dietary total antioxidant capacity (DTAC) and overall survival (OS) in patients with ovarian cancer (OC). Methods A validated 111-item food frequency questionnaire was used to assess their pre- and post-diagnosis dieta...
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2025-08-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-025-01185-7 |
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| author | Dong-Hui Huang Lei Wang Xiao-Ying Li Ying Qin Fang-Hua Liu Yi-Zi Li He-Li Xu Fan Cao Lang Wu Yi-Fan Wei Song Gao Ting-Ting Gong Yu-Hong Zhao Qi-Jun Wu |
| author_facet | Dong-Hui Huang Lei Wang Xiao-Ying Li Ying Qin Fang-Hua Liu Yi-Zi Li He-Li Xu Fan Cao Lang Wu Yi-Fan Wei Song Gao Ting-Ting Gong Yu-Hong Zhao Qi-Jun Wu |
| author_sort | Dong-Hui Huang |
| collection | DOAJ |
| description | Abstract Background The current study aims to investigate the association between dietary total antioxidant capacity (DTAC) and overall survival (OS) in patients with ovarian cancer (OC). Methods A validated 111-item food frequency questionnaire was used to assess their pre- and post-diagnosis dietary intake. DTAC is represented by ferric-reducing ability of plasma (FRAP), total oxygen radical absorbance capacity (TORAC), hydrophilic oxygen radical absorbance capacity (HORAC), lipophilic oxygen radical absorbance capacity (LORAC), and total phenolics (TP). The OS was determined by both passive and active follow-up. Results A total of 531 patients with OC was involved in this study. High post-diagnosis FRAP (HRT3 vs. T1=0.65, 95%CI = 0.42–0.99), post-diagnosis TORAC (HRT3 vs. T1=0.68, 95%CI = 0.47–0.98), and pre-diagnosis LORAC (HRT3 vs. T1=0.62, 95%CI = 0.43–0.89) had statistically significant association with an improved OS. Additionally, increased DTAC consumption (FRAP: HR Low−Medium=0.53, 95%CI = 0.30–0.95; FRAP: HR Low−High=0.46, 95%CI = 0.23–0.93; LORAC: HR Medium−High=0.50, 95%CI = 0.27–0.91), as well as maintaining high or medium DTAC consumption (TORAC: HR Medium−Medium=0.46, 95%CI = 0.26–0.83; TORAC: HR High−High=0.57, 95%CI = 0.34–0.96; LORAC: HR High−Medium=0.43, 95%CI = 0.23–0.82), improved the OS in patients with OC. Conclusions Increased pre- and post-diagnosis DTAC intake, and maintaining moderate or high DTAC intake after diagnosis, may be associated with enhanced OS in patients with OC. |
| format | Article |
| id | doaj-art-97f679c683f5429f86cc3398e4672dec |
| institution | Kabale University |
| issn | 1475-2891 |
| language | English |
| publishDate | 2025-08-01 |
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| series | Nutrition Journal |
| spelling | doaj-art-97f679c683f5429f86cc3398e4672dec2025-08-20T03:45:47ZengBMCNutrition Journal1475-28912025-08-0124111210.1186/s12937-025-01185-7Pre- and post-diagnosis dietary total antioxidant capacity and overall survival in patients with ovarian cancer: a prospective cohort studyDong-Hui Huang0Lei Wang1Xiao-Ying Li2Ying Qin3Fang-Hua Liu4Yi-Zi Li5He-Li Xu6Fan Cao7Lang Wu8Yi-Fan Wei9Song Gao10Ting-Ting Gong11Yu-Hong Zhao12Qi-Jun Wu13Department of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityCancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at ManoaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityAbstract Background The current study aims to investigate the association between dietary total antioxidant capacity (DTAC) and overall survival (OS) in patients with ovarian cancer (OC). Methods A validated 111-item food frequency questionnaire was used to assess their pre- and post-diagnosis dietary intake. DTAC is represented by ferric-reducing ability of plasma (FRAP), total oxygen radical absorbance capacity (TORAC), hydrophilic oxygen radical absorbance capacity (HORAC), lipophilic oxygen radical absorbance capacity (LORAC), and total phenolics (TP). The OS was determined by both passive and active follow-up. Results A total of 531 patients with OC was involved in this study. High post-diagnosis FRAP (HRT3 vs. T1=0.65, 95%CI = 0.42–0.99), post-diagnosis TORAC (HRT3 vs. T1=0.68, 95%CI = 0.47–0.98), and pre-diagnosis LORAC (HRT3 vs. T1=0.62, 95%CI = 0.43–0.89) had statistically significant association with an improved OS. Additionally, increased DTAC consumption (FRAP: HR Low−Medium=0.53, 95%CI = 0.30–0.95; FRAP: HR Low−High=0.46, 95%CI = 0.23–0.93; LORAC: HR Medium−High=0.50, 95%CI = 0.27–0.91), as well as maintaining high or medium DTAC consumption (TORAC: HR Medium−Medium=0.46, 95%CI = 0.26–0.83; TORAC: HR High−High=0.57, 95%CI = 0.34–0.96; LORAC: HR High−Medium=0.43, 95%CI = 0.23–0.82), improved the OS in patients with OC. Conclusions Increased pre- and post-diagnosis DTAC intake, and maintaining moderate or high DTAC intake after diagnosis, may be associated with enhanced OS in patients with OC.https://doi.org/10.1186/s12937-025-01185-7Cohort studyDietary total antioxidant capacityNutritionOvarian cancerOverall survivalPrognosis |
| spellingShingle | Dong-Hui Huang Lei Wang Xiao-Ying Li Ying Qin Fang-Hua Liu Yi-Zi Li He-Li Xu Fan Cao Lang Wu Yi-Fan Wei Song Gao Ting-Ting Gong Yu-Hong Zhao Qi-Jun Wu Pre- and post-diagnosis dietary total antioxidant capacity and overall survival in patients with ovarian cancer: a prospective cohort study Nutrition Journal Cohort study Dietary total antioxidant capacity Nutrition Ovarian cancer Overall survival Prognosis |
| title | Pre- and post-diagnosis dietary total antioxidant capacity and overall survival in patients with ovarian cancer: a prospective cohort study |
| title_full | Pre- and post-diagnosis dietary total antioxidant capacity and overall survival in patients with ovarian cancer: a prospective cohort study |
| title_fullStr | Pre- and post-diagnosis dietary total antioxidant capacity and overall survival in patients with ovarian cancer: a prospective cohort study |
| title_full_unstemmed | Pre- and post-diagnosis dietary total antioxidant capacity and overall survival in patients with ovarian cancer: a prospective cohort study |
| title_short | Pre- and post-diagnosis dietary total antioxidant capacity and overall survival in patients with ovarian cancer: a prospective cohort study |
| title_sort | pre and post diagnosis dietary total antioxidant capacity and overall survival in patients with ovarian cancer a prospective cohort study |
| topic | Cohort study Dietary total antioxidant capacity Nutrition Ovarian cancer Overall survival Prognosis |
| url | https://doi.org/10.1186/s12937-025-01185-7 |
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