Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study
BackgroundCarotid atherosclerosis (CAS), a key precipitator of cardiovascular incidents, is linked to postprandial triglyceride-rich lipoproteins (TRL), as reflected by elevated triglycerides (TG) and remnant cholesterol (RC). This study explores the oral fat tolerance test (OFTT) for its predictive...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1502792/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849722865382850560 |
|---|---|
| author | Yilin Hou Yilin Hou Peipei Tian Peipei Tian Guangyao Song Guangyao Song Guangyao Song An Song Dandan Liu Dandan Liu Zhimin Wang Zhimin Wang Yihe Shi Yihe Shi Yale Tang Yale Tang Xiaoyu Wang Xiaoyu Wang Luxuan Li Luxuan Li Luping Ren Luping Ren Luping Ren |
| author_facet | Yilin Hou Yilin Hou Peipei Tian Peipei Tian Guangyao Song Guangyao Song Guangyao Song An Song Dandan Liu Dandan Liu Zhimin Wang Zhimin Wang Yihe Shi Yihe Shi Yale Tang Yale Tang Xiaoyu Wang Xiaoyu Wang Luxuan Li Luxuan Li Luping Ren Luping Ren Luping Ren |
| author_sort | Yilin Hou |
| collection | DOAJ |
| description | BackgroundCarotid atherosclerosis (CAS), a key precipitator of cardiovascular incidents, is linked to postprandial triglyceride-rich lipoproteins (TRL), as reflected by elevated triglycerides (TG) and remnant cholesterol (RC). This study explores the oral fat tolerance test (OFTT) for its predictive value in CAS, using postprandial TRL levels as a diagnostic biomarker.MethodsA total of 107 volunteers with normal fasting lipid profiles and no CAS at baseline were included. They received an OFTT after consuming a meal containing 60% fat (1500 kcal). Serum lipid profiles were monitored at fasting and 2, 4, 6, 8, and 10 h postprandially. The participants were categorized into postprandial normotriglyceridemia and postprandial hypertriglyceridemia groups based on their postprandial TG levels. After a 6-year follow-up, fasting lipid profiles and CAS status were reassessed. The baseline fasting and postprandial lipid levels in the CAS and non-CAS groups were compared. Repeated-measures analysis of variance was used to analyze the postprandial lipid profiles across different groups. Logistic regression models were constructed to assess the effects of postprandial TG and RC levels on CAS incidence.ResultsThe incidence of CAS in the postprandial hypertriglyceridemia group was 66.0%, which was significantly higher than the 13.3% observed in the postprandial normotriglyceridemia group (P < 0.001). In the CAS group, postprandial TG and RC levels peaked 4 h after a high-fat meal and did not return to fasting levels, even after 10 h. The levels of 4h-postprandial TG (TG4h), maximum postprandial TG (TGmax), 4h-postprandial RC (RC4h), and maximum postprandial RC (RCmax) were significantly higher in the CAS group than in the non-CAS group (P < 0.05). At baseline, TG4h (P < 0.001), TGmax (P = 0.006), RC4h (P < 0.001), and RCmax (P = 0.003) were statistically significant predictors of CAS, whereas fasting TG (P = 0.200) and fasting RC (P = 0.200) were not significantly associated with CAS.ConclusionThe standardized OFTT has predictive value for CAS, and elevated TRL levels after a high-fat meal in individuals with normal fasting lipid profiles may serve as an early marker for CAS. |
| format | Article |
| id | doaj-art-97f4177155c24a5ebbab0969aa9cb6e5 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-97f4177155c24a5ebbab0969aa9cb6e52025-08-20T03:11:11ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15027921502792Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up studyYilin Hou0Yilin Hou1Peipei Tian2Peipei Tian3Guangyao Song4Guangyao Song5Guangyao Song6An Song7Dandan Liu8Dandan Liu9Zhimin Wang10Zhimin Wang11Yihe Shi12Yihe Shi13Yale Tang14Yale Tang15Xiaoyu Wang16Xiaoyu Wang17Luxuan Li18Luxuan Li19Luping Ren20Luping Ren21Luping Ren22Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaHebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, National Commission of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaHebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, Hebei, ChinaBackgroundCarotid atherosclerosis (CAS), a key precipitator of cardiovascular incidents, is linked to postprandial triglyceride-rich lipoproteins (TRL), as reflected by elevated triglycerides (TG) and remnant cholesterol (RC). This study explores the oral fat tolerance test (OFTT) for its predictive value in CAS, using postprandial TRL levels as a diagnostic biomarker.MethodsA total of 107 volunteers with normal fasting lipid profiles and no CAS at baseline were included. They received an OFTT after consuming a meal containing 60% fat (1500 kcal). Serum lipid profiles were monitored at fasting and 2, 4, 6, 8, and 10 h postprandially. The participants were categorized into postprandial normotriglyceridemia and postprandial hypertriglyceridemia groups based on their postprandial TG levels. After a 6-year follow-up, fasting lipid profiles and CAS status were reassessed. The baseline fasting and postprandial lipid levels in the CAS and non-CAS groups were compared. Repeated-measures analysis of variance was used to analyze the postprandial lipid profiles across different groups. Logistic regression models were constructed to assess the effects of postprandial TG and RC levels on CAS incidence.ResultsThe incidence of CAS in the postprandial hypertriglyceridemia group was 66.0%, which was significantly higher than the 13.3% observed in the postprandial normotriglyceridemia group (P < 0.001). In the CAS group, postprandial TG and RC levels peaked 4 h after a high-fat meal and did not return to fasting levels, even after 10 h. The levels of 4h-postprandial TG (TG4h), maximum postprandial TG (TGmax), 4h-postprandial RC (RC4h), and maximum postprandial RC (RCmax) were significantly higher in the CAS group than in the non-CAS group (P < 0.05). At baseline, TG4h (P < 0.001), TGmax (P = 0.006), RC4h (P < 0.001), and RCmax (P = 0.003) were statistically significant predictors of CAS, whereas fasting TG (P = 0.200) and fasting RC (P = 0.200) were not significantly associated with CAS.ConclusionThe standardized OFTT has predictive value for CAS, and elevated TRL levels after a high-fat meal in individuals with normal fasting lipid profiles may serve as an early marker for CAS.https://www.frontiersin.org/articles/10.3389/fendo.2025.1502792/fullatherosclerotic cardiovascular diseasecarotid atherosclerosisremnant cholesteroltriglyceridespostprandialoral fat tolerance test |
| spellingShingle | Yilin Hou Yilin Hou Peipei Tian Peipei Tian Guangyao Song Guangyao Song Guangyao Song An Song Dandan Liu Dandan Liu Zhimin Wang Zhimin Wang Yihe Shi Yihe Shi Yale Tang Yale Tang Xiaoyu Wang Xiaoyu Wang Luxuan Li Luxuan Li Luping Ren Luping Ren Luping Ren Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study Frontiers in Endocrinology atherosclerotic cardiovascular disease carotid atherosclerosis remnant cholesterol triglycerides postprandial oral fat tolerance test |
| title | Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study |
| title_full | Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study |
| title_fullStr | Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study |
| title_full_unstemmed | Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study |
| title_short | Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study |
| title_sort | postprandial triglyceride rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles a prospective follow up study |
| topic | atherosclerotic cardiovascular disease carotid atherosclerosis remnant cholesterol triglycerides postprandial oral fat tolerance test |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1502792/full |
| work_keys_str_mv | AT yilinhou postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT yilinhou postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT peipeitian postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT peipeitian postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT guangyaosong postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT guangyaosong postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT guangyaosong postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT ansong postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT dandanliu postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT dandanliu postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT zhiminwang postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT zhiminwang postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT yiheshi postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT yiheshi postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT yaletang postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT yaletang postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT xiaoyuwang postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT xiaoyuwang postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT luxuanli postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT luxuanli postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT lupingren postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT lupingren postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy AT lupingren postprandialtriglyceriderichlipoproteinsaspredictorsofcarotidatherosclerosisinindividualswithnormalfastinglipidprofilesaprospectivefollowupstudy |