Prospective Study of Antibiotic Prophylaxis for Prostate Biopsy Involving >1100 Men
We aimed to compare infection rates for two 3-day antibiotic prophylaxis regimens for transrectal ultrasound-guided prostate biopsy (TRUSgbp) and demonstrate local microbiological trends. In 2008, 558 men and, in 2009, 625 men had TRUSgpb. Regimen 1 (2008) comprised 400 mg Ofloxacin immediately befo...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/650858 |
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| author | Rustom P. Manecksha Gregory J. Nason Ivor M. Cullen Jérôme P. Fennell Elizabeth McEvoy Ted McDermott Robert J. Flynn Ronald Grainger John A. Thornhill |
| author_facet | Rustom P. Manecksha Gregory J. Nason Ivor M. Cullen Jérôme P. Fennell Elizabeth McEvoy Ted McDermott Robert J. Flynn Ronald Grainger John A. Thornhill |
| author_sort | Rustom P. Manecksha |
| collection | DOAJ |
| description | We aimed to compare infection rates for two 3-day antibiotic prophylaxis regimens for transrectal ultrasound-guided prostate biopsy (TRUSgbp) and demonstrate local microbiological trends. In 2008, 558 men and, in 2009, 625 men had TRUSgpb. Regimen 1 (2008) comprised 400 mg Ofloxacin immediately before biopsy and 200 mg 12-hourly for 3 days. Regimen 2 (2009) comprised Ofloxacin 200 mg 12-hourly for 3 days commencing 24 hours before biopsy. 20/558 (3.6%) men had febrile episodes with regimen 1 and 10/625 (1.6%) men with regimen 2 (𝑃=0.03). E. coli was the most frequently isolated organism. Overall, 7/13 (54%) of positive urine cultures were quinolone resistant and (5/13) 40% were multidrug resistant. Overall, 5/9 (56%) patients with septicaemia were quinolone resistant. All patients were sensitive to Meropenem. There was 1 (0.2%) death with regimen 1. Commencing Ofloxacin 24 hours before TRUSgpb reduced the incidence of febrile episodes significantly. We observed the emergence of quinolone and multidrug-resistant E. coli. Meropenem should be considered for unresolving sepsis. |
| format | Article |
| id | doaj-art-97f304968a7248009bb895690d9a841e |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-97f304968a7248009bb895690d9a841e2025-02-03T01:32:44ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/650858650858Prospective Study of Antibiotic Prophylaxis for Prostate Biopsy Involving >1100 MenRustom P. Manecksha0Gregory J. Nason1Ivor M. Cullen2Jérôme P. Fennell3Elizabeth McEvoy4Ted McDermott5Robert J. Flynn6Ronald Grainger7John A. Thornhill8Department of Urology, Adelaide and Meath Hospital, Tallaght, Dublin 24, IrelandDepartment of Urology, Adelaide and Meath Hospital, Tallaght, Dublin 24, IrelandDepartment of Urology, Adelaide and Meath Hospital, Tallaght, Dublin 24, IrelandDepartment of Microbiology, Adelaide and Meath Hospital, Tallaght, Dublin 24, IrelandDepartment of Urology, Adelaide and Meath Hospital, Tallaght, Dublin 24, IrelandDepartment of Urology, Adelaide and Meath Hospital, Tallaght, Dublin 24, IrelandDepartment of Urology, Adelaide and Meath Hospital, Tallaght, Dublin 24, IrelandDepartment of Urology, Adelaide and Meath Hospital, Tallaght, Dublin 24, IrelandDepartment of Urology, Adelaide and Meath Hospital, Tallaght, Dublin 24, IrelandWe aimed to compare infection rates for two 3-day antibiotic prophylaxis regimens for transrectal ultrasound-guided prostate biopsy (TRUSgbp) and demonstrate local microbiological trends. In 2008, 558 men and, in 2009, 625 men had TRUSgpb. Regimen 1 (2008) comprised 400 mg Ofloxacin immediately before biopsy and 200 mg 12-hourly for 3 days. Regimen 2 (2009) comprised Ofloxacin 200 mg 12-hourly for 3 days commencing 24 hours before biopsy. 20/558 (3.6%) men had febrile episodes with regimen 1 and 10/625 (1.6%) men with regimen 2 (𝑃=0.03). E. coli was the most frequently isolated organism. Overall, 7/13 (54%) of positive urine cultures were quinolone resistant and (5/13) 40% were multidrug resistant. Overall, 5/9 (56%) patients with septicaemia were quinolone resistant. All patients were sensitive to Meropenem. There was 1 (0.2%) death with regimen 1. Commencing Ofloxacin 24 hours before TRUSgpb reduced the incidence of febrile episodes significantly. We observed the emergence of quinolone and multidrug-resistant E. coli. Meropenem should be considered for unresolving sepsis.http://dx.doi.org/10.1100/2012/650858 |
| spellingShingle | Rustom P. Manecksha Gregory J. Nason Ivor M. Cullen Jérôme P. Fennell Elizabeth McEvoy Ted McDermott Robert J. Flynn Ronald Grainger John A. Thornhill Prospective Study of Antibiotic Prophylaxis for Prostate Biopsy Involving >1100 Men The Scientific World Journal |
| title | Prospective Study of Antibiotic Prophylaxis for Prostate Biopsy Involving >1100 Men |
| title_full | Prospective Study of Antibiotic Prophylaxis for Prostate Biopsy Involving >1100 Men |
| title_fullStr | Prospective Study of Antibiotic Prophylaxis for Prostate Biopsy Involving >1100 Men |
| title_full_unstemmed | Prospective Study of Antibiotic Prophylaxis for Prostate Biopsy Involving >1100 Men |
| title_short | Prospective Study of Antibiotic Prophylaxis for Prostate Biopsy Involving >1100 Men |
| title_sort | prospective study of antibiotic prophylaxis for prostate biopsy involving 1100 men |
| url | http://dx.doi.org/10.1100/2012/650858 |
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