A randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancer
Abstract Background The purpose of this study is to evaluate the effect of oxycodone and sufentanil on postoperative analgesia and immune function in patients with laparoscopic resection of colorectal cancer (CRC), as well as the serum level of inflammatory cytokine. Methods 40 patients from August...
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2025-02-01
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| Online Access: | https://doi.org/10.1186/s12871-025-02922-5 |
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| author | Chunmei Lin Zhiqiao Xu XinLiang Hong Wei Xiaoping Wang |
| author_facet | Chunmei Lin Zhiqiao Xu XinLiang Hong Wei Xiaoping Wang |
| author_sort | Chunmei Lin |
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| description | Abstract Background The purpose of this study is to evaluate the effect of oxycodone and sufentanil on postoperative analgesia and immune function in patients with laparoscopic resection of colorectal cancer (CRC), as well as the serum level of inflammatory cytokine. Methods 40 patients from August 2023 to August 2024 in Shenzhen Nanshan Hospital undergoing laparoscopic resection of CRC were randomly divided into Group O (n = 20) and Group S (n = 20). The visual analog scale (VAS) score and serial blood samples were assessed during perioperative period. The primary outcomes were VAS scores and immune indicators (including IL-2, C3, C4, IgG, IgA, IgE, IgM, CD3+, CD4+, CD8+ and CD4+/CD8+) at 24 h and 72 h post-surgery at 24 h and 72 h after surgery. The secondary outcomes were inflammatory markers (including IL-4, IL-6, IL-10, TNF-a and INF-y) at 24 h and 72 h after surgery. Results The VAS scores at cough in Group O at 24 h and 72 h postoperative were lower than those in Group S (p < 0.001). No significant difference was found in VAS scores at rest between the two groups (P > 0.05). The immune indicators did not show significant changes after using oxycodone or sufentanil for patient-controlled intravenous analgesia (PCIA), respectively. There was no significant difference in inflammatory factors at 24 h and 72 h after surgery between the Group O and Group S. Conclusion Oxycodone is more effective than sufentanil in alleviating visceral pain, although it does not surpass sufentanil in managing cutting pain. In addition, there is no significant superiority in the effects of oxycodone on immune function and inflammatory cytokine release compared to sufentanil. Trial registration Chinese Clinical Trial Registry (ChiCTR2400089072). |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-02-01 |
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| series | BMC Anesthesiology |
| spelling | doaj-art-97f2a49c6b184a82b377612164b561102025-02-09T12:51:58ZengBMCBMC Anesthesiology1471-22532025-02-012511810.1186/s12871-025-02922-5A randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancerChunmei Lin0Zhiqiao Xu1XinLiang2Hong Wei3Xiaoping Wang4The First Clinical Medical School, Jinan UniversityDepartment of Anaesthesiology, Shenzhen Nanshan HospitalDepartment of Anaesthesiology, Shenzhen Nanshan HospitalDepartment of Anaesthesiology, Shenzhen Nanshan HospitalDepartment of Pain Management, the First Affiliated Hospital of Jinan UniversityAbstract Background The purpose of this study is to evaluate the effect of oxycodone and sufentanil on postoperative analgesia and immune function in patients with laparoscopic resection of colorectal cancer (CRC), as well as the serum level of inflammatory cytokine. Methods 40 patients from August 2023 to August 2024 in Shenzhen Nanshan Hospital undergoing laparoscopic resection of CRC were randomly divided into Group O (n = 20) and Group S (n = 20). The visual analog scale (VAS) score and serial blood samples were assessed during perioperative period. The primary outcomes were VAS scores and immune indicators (including IL-2, C3, C4, IgG, IgA, IgE, IgM, CD3+, CD4+, CD8+ and CD4+/CD8+) at 24 h and 72 h post-surgery at 24 h and 72 h after surgery. The secondary outcomes were inflammatory markers (including IL-4, IL-6, IL-10, TNF-a and INF-y) at 24 h and 72 h after surgery. Results The VAS scores at cough in Group O at 24 h and 72 h postoperative were lower than those in Group S (p < 0.001). No significant difference was found in VAS scores at rest between the two groups (P > 0.05). The immune indicators did not show significant changes after using oxycodone or sufentanil for patient-controlled intravenous analgesia (PCIA), respectively. There was no significant difference in inflammatory factors at 24 h and 72 h after surgery between the Group O and Group S. Conclusion Oxycodone is more effective than sufentanil in alleviating visceral pain, although it does not surpass sufentanil in managing cutting pain. In addition, there is no significant superiority in the effects of oxycodone on immune function and inflammatory cytokine release compared to sufentanil. Trial registration Chinese Clinical Trial Registry (ChiCTR2400089072).https://doi.org/10.1186/s12871-025-02922-5OxycodoneSufentanilLaparoscopic resection of colorectal cancerPostoperative analgesiaImmune function |
| spellingShingle | Chunmei Lin Zhiqiao Xu XinLiang Hong Wei Xiaoping Wang A randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancer BMC Anesthesiology Oxycodone Sufentanil Laparoscopic resection of colorectal cancer Postoperative analgesia Immune function |
| title | A randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancer |
| title_full | A randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancer |
| title_fullStr | A randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancer |
| title_full_unstemmed | A randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancer |
| title_short | A randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancer |
| title_sort | randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancer |
| topic | Oxycodone Sufentanil Laparoscopic resection of colorectal cancer Postoperative analgesia Immune function |
| url | https://doi.org/10.1186/s12871-025-02922-5 |
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