Eliciting specialized metabolites from marine microalgae using abiotic stress
Advanced mass spectrometry and molecular networking techniques have led to an increase in the discovery of novel metabolites from bacteria and fungi. However, a systematic approach to exploring the metabolite profiles of microalgae in response to stress has not been performed. Unlocking the chemical...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Applied Phycology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/26388081.2023.2280928 |
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| author | Alison H. Hughes Katherine R. Duncan |
| author_facet | Alison H. Hughes Katherine R. Duncan |
| author_sort | Alison H. Hughes |
| collection | DOAJ |
| description | Advanced mass spectrometry and molecular networking techniques have led to an increase in the discovery of novel metabolites from bacteria and fungi. However, a systematic approach to exploring the metabolite profiles of microalgae in response to stress has not been performed. Unlocking the chemical potential of microalgae could provide further biotechnology applications in nutraceutical, biofuel, and cosmetic industries. This study explored the changes in metabolite production of strains of the three microalgae Dunaliella primolecta, Nannochloropsis oculata, and Phaeodactylum tricornutum cultured under varying nitrate, NaCl, salinity and pH conditions. A total of 2284 metabolites were detected across all strains and conditions, with 49% of those metabolites specific to cultures grown under stress (i.e., not present in the control). From comparison with 33 libraries of mass spectral data, only five metabolites were identified, stressing the need for more open-access natural product databases specifically focused on microalgae. |
| format | Article |
| id | doaj-art-97f257d4b66a48b5843b57c54e32e624 |
| institution | DOAJ |
| issn | 2638-8081 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Applied Phycology |
| spelling | doaj-art-97f257d4b66a48b5843b57c54e32e6242025-08-20T02:48:43ZengTaylor & Francis GroupApplied Phycology2638-80812024-12-015111110.1080/26388081.2023.2280928Eliciting specialized metabolites from marine microalgae using abiotic stressAlison H. Hughes0Katherine R. Duncan1University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, UKUniversity of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, UKAdvanced mass spectrometry and molecular networking techniques have led to an increase in the discovery of novel metabolites from bacteria and fungi. However, a systematic approach to exploring the metabolite profiles of microalgae in response to stress has not been performed. Unlocking the chemical potential of microalgae could provide further biotechnology applications in nutraceutical, biofuel, and cosmetic industries. This study explored the changes in metabolite production of strains of the three microalgae Dunaliella primolecta, Nannochloropsis oculata, and Phaeodactylum tricornutum cultured under varying nitrate, NaCl, salinity and pH conditions. A total of 2284 metabolites were detected across all strains and conditions, with 49% of those metabolites specific to cultures grown under stress (i.e., not present in the control). From comparison with 33 libraries of mass spectral data, only five metabolites were identified, stressing the need for more open-access natural product databases specifically focused on microalgae.https://www.tandfonline.com/doi/10.1080/26388081.2023.2280928Microalgaemolecular networkingmetabolitesnitratesalinitypH |
| spellingShingle | Alison H. Hughes Katherine R. Duncan Eliciting specialized metabolites from marine microalgae using abiotic stress Applied Phycology Microalgae molecular networking metabolites nitrate salinity pH |
| title | Eliciting specialized metabolites from marine microalgae using abiotic stress |
| title_full | Eliciting specialized metabolites from marine microalgae using abiotic stress |
| title_fullStr | Eliciting specialized metabolites from marine microalgae using abiotic stress |
| title_full_unstemmed | Eliciting specialized metabolites from marine microalgae using abiotic stress |
| title_short | Eliciting specialized metabolites from marine microalgae using abiotic stress |
| title_sort | eliciting specialized metabolites from marine microalgae using abiotic stress |
| topic | Microalgae molecular networking metabolites nitrate salinity pH |
| url | https://www.tandfonline.com/doi/10.1080/26388081.2023.2280928 |
| work_keys_str_mv | AT alisonhhughes elicitingspecializedmetabolitesfrommarinemicroalgaeusingabioticstress AT katherinerduncan elicitingspecializedmetabolitesfrommarinemicroalgaeusingabioticstress |