Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies

Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies

Introduction Family history is a risk factor for chronic obstructive pulmonary disease (COPD). We previously developed a COPD risk score from genome-wide genetic markers (Polygenic Risk Score, PRS). Whether the PRS and family history provide complementary or redundant information for predicting COPD...

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Main Authors: Matthew Moll, Sharon M. Lutz, Auyon J. Ghosh, Phuwanat Sakornsakolpat, Craig P. Hersh, Terri H. Beaty, Frank Dudbridge, Martin D. Tobin, Murray A. Mittleman, Edwin K. Silverman, Brian D. Hobbs, Michael H. Cho
Format: Article
Language:English
Published: BMJ Publishing Group 2020-09-01
Series:BMJ Open Respiratory Research
Online Access:https://bmjopenrespres.bmj.com/content/7/1/e000755.full
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