Diagnosis Dilemma of Angioimmunoblastic T-Cell Lymphoma in Tuberculosis Endemic Region
Angioimmunoblastic T-cell lymphoma (AITL) is a rare hematologic malignancy recognized in the WHO 2016 classification as a clinical and histological entity. It is a very poorly described disease in Africa due to its rarity and diagnostic difficulties, particularly differential diagnosis with tubercul...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/8824843 |
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| author | S. A. Touré M. Seck A B. Diallo E. H. D. Niang M. Keita M. F. Dabo B. F. Faye S. Diop |
| author_facet | S. A. Touré M. Seck A B. Diallo E. H. D. Niang M. Keita M. F. Dabo B. F. Faye S. Diop |
| author_sort | S. A. Touré |
| collection | DOAJ |
| description | Angioimmunoblastic T-cell lymphoma (AITL) is a rare hematologic malignancy recognized in the WHO 2016 classification as a clinical and histological entity. It is a very poorly described disease in Africa due to its rarity and diagnostic difficulties, particularly differential diagnosis with tuberculosis. Here, we report a 57-year-old man who presented with fever, weight loss, and lymphadenopathies. The diagnosis of tuberculosis was carried out based on lymph node fine needle aspiration showing the image of tuberculous adenitis and CT images in favor of necrotic lymphadenopathies. The presence of autoantibodies and the failure of tuberculosis treatment led us to perform a biopsy with immunostaining that confirmed pathological features of AITL. The patient was treated by CHOP-based chemotherapy, and complete remission was achieved. This case highlights the difficulty of recognizing AITL and the importance of considering other potential differential diagnoses of tuberculosis in the endemic region. |
| format | Article |
| id | doaj-art-97ed74ca57bc4dfca354d77100076a90 |
| institution | DOAJ |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-97ed74ca57bc4dfca354d77100076a902025-08-20T03:20:39ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/88248438824843Diagnosis Dilemma of Angioimmunoblastic T-Cell Lymphoma in Tuberculosis Endemic RegionS. A. Touré0M. Seck1A B. Diallo2E. H. D. Niang3M. Keita4M. F. Dabo5B. F. Faye6S. Diop7Hematology Department, Cheikh Anta Diop University, Dakar, SenegalHematology Department, Cheikh Anta Diop University, Dakar, SenegalHematology Department, Cheikh Anta Diop University, Dakar, SenegalHematology Department, Cheikh Anta Diop University, Dakar, SenegalHematology Department, Cheikh Anta Diop University, Dakar, SenegalHematology Department, Cheikh Anta Diop University, Dakar, SenegalHematology Department, Cheikh Anta Diop University, Dakar, SenegalHematology Department, Cheikh Anta Diop University, Dakar, SenegalAngioimmunoblastic T-cell lymphoma (AITL) is a rare hematologic malignancy recognized in the WHO 2016 classification as a clinical and histological entity. It is a very poorly described disease in Africa due to its rarity and diagnostic difficulties, particularly differential diagnosis with tuberculosis. Here, we report a 57-year-old man who presented with fever, weight loss, and lymphadenopathies. The diagnosis of tuberculosis was carried out based on lymph node fine needle aspiration showing the image of tuberculous adenitis and CT images in favor of necrotic lymphadenopathies. The presence of autoantibodies and the failure of tuberculosis treatment led us to perform a biopsy with immunostaining that confirmed pathological features of AITL. The patient was treated by CHOP-based chemotherapy, and complete remission was achieved. This case highlights the difficulty of recognizing AITL and the importance of considering other potential differential diagnoses of tuberculosis in the endemic region.http://dx.doi.org/10.1155/2020/8824843 |
| spellingShingle | S. A. Touré M. Seck A B. Diallo E. H. D. Niang M. Keita M. F. Dabo B. F. Faye S. Diop Diagnosis Dilemma of Angioimmunoblastic T-Cell Lymphoma in Tuberculosis Endemic Region Case Reports in Hematology |
| title | Diagnosis Dilemma of Angioimmunoblastic T-Cell Lymphoma in Tuberculosis Endemic Region |
| title_full | Diagnosis Dilemma of Angioimmunoblastic T-Cell Lymphoma in Tuberculosis Endemic Region |
| title_fullStr | Diagnosis Dilemma of Angioimmunoblastic T-Cell Lymphoma in Tuberculosis Endemic Region |
| title_full_unstemmed | Diagnosis Dilemma of Angioimmunoblastic T-Cell Lymphoma in Tuberculosis Endemic Region |
| title_short | Diagnosis Dilemma of Angioimmunoblastic T-Cell Lymphoma in Tuberculosis Endemic Region |
| title_sort | diagnosis dilemma of angioimmunoblastic t cell lymphoma in tuberculosis endemic region |
| url | http://dx.doi.org/10.1155/2020/8824843 |
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