Investigating the modulatory effects of lactoferrin on depressed rats through 16S rDNA gene sequencing and LC–MS metabolomics analysis

Investigating the modulatory effects of lactoferrin on depressed rats through 16S rDNA gene sequencing and LC–MS metabolomics analysis

Abstract Lactoferrin is a natural multifunctional glycoprotein with potential antidepressant-like effects. However, the mechanism of its antidepressant effect has not been explored from the perspective of gut flora metabolism. Therefore, we employed both 16S rDNA gene sequencing and LC–MS metabolomi...

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Bibliographic Details
Main Authors: Jing Zhang, Hongmei Xin, Wuji Wang, Yanyi Li, Riga Wu, Lisi Wei, Si Su, Xiaohong Wang, Xiujuan Wang, Xiaojuan Wang, Li Li, Rilebagen Hu
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Scientific Reports
Subjects:
Lactoferrin
Depression
Gut microbiota
Metabolic disorders
Microbiota-gut-brain axis
Online Access:https://doi.org/10.1038/s41598-024-72793-2
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