Choroidal Melanoma Treated with Linear Accelerator-based Hypofractionated Stereotactic Radiotherapy: First Case of Globe Conservation in Uveal Melanoma from the Philippines
Objective: This is a case report of a 60-year-old woman with a juxtapapillary choroidal melanoma who underwent globe-sparing treatment using linear-accelerator (LINAC)-based hypofractionated stereotactic radiotherapy (FSRT). Methods: Clinical data, ophthalmologic findings, and imaging results were...
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| Format: | Article |
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Philippine Academy of Ophthalmology
2025-06-01
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| Series: | Philippine Journal of Ophthalmology |
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| Online Access: | https://paojournal.com/index.php/pjo/article/view/540 |
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| author | Raymund V. Tanchuling, MD Andrei P. Martin, MD |
| author_facet | Raymund V. Tanchuling, MD Andrei P. Martin, MD |
| author_sort | Raymund V. Tanchuling, MD |
| collection | DOAJ |
| description | Objective: This is a case report of a 60-year-old woman with a juxtapapillary choroidal melanoma who underwent globe-sparing treatment using linear-accelerator (LINAC)-based hypofractionated stereotactic radiotherapy (FSRT).
Methods: Clinical data, ophthalmologic findings, and imaging results were obtained through retrospective chart review.
Results: At three months and nine months post-treatment, tumor thickness decreased by 20.5% (from 13.00 mm to 10.34 mm) and 33.2% (to 8.69 mm), respectively. Partial resolution of subretinal fluid and vitreous hemorrhage was confirmed clinically and by B-scan. No metastatic spread was detected on liver ultrasound and chest radiography. Best-corrected visual acuity in the treated eye remained stable at hand motion. Radiation-induced dry eye was managed effectively with preservative-free sodium hyaluronate eye drops.
Conclusion: LINAC-based hypofractionated FSRT achieved marked local control and tumor regression in this case of a medium-large, juxtapapillary choroidal melanoma, while preserving the globe and the baseline vision. In regions without access to plaque brachytherapy, this technique offers a practical, cost-efficient, and multidisciplinary approach to eye-conserving therapy. |
| format | Article |
| id | doaj-art-97e9666d539542e5a012efcbb5d2ed5e |
| institution | OA Journals |
| issn | 0031-7659 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Philippine Academy of Ophthalmology |
| record_format | Article |
| series | Philippine Journal of Ophthalmology |
| spelling | doaj-art-97e9666d539542e5a012efcbb5d2ed5e2025-08-20T02:37:14ZengPhilippine Academy of OphthalmologyPhilippine Journal of Ophthalmology0031-76592025-06-015016471540Choroidal Melanoma Treated with Linear Accelerator-based Hypofractionated Stereotactic Radiotherapy: First Case of Globe Conservation in Uveal Melanoma from the PhilippinesRaymund V. Tanchuling, MD0Andrei P. Martin, MD1St. Luke’s Medical Center, Quezon City, PhilippinesSt. Luke’s Medical Center, Quezon City, PhilippinesObjective: This is a case report of a 60-year-old woman with a juxtapapillary choroidal melanoma who underwent globe-sparing treatment using linear-accelerator (LINAC)-based hypofractionated stereotactic radiotherapy (FSRT). Methods: Clinical data, ophthalmologic findings, and imaging results were obtained through retrospective chart review. Results: At three months and nine months post-treatment, tumor thickness decreased by 20.5% (from 13.00 mm to 10.34 mm) and 33.2% (to 8.69 mm), respectively. Partial resolution of subretinal fluid and vitreous hemorrhage was confirmed clinically and by B-scan. No metastatic spread was detected on liver ultrasound and chest radiography. Best-corrected visual acuity in the treated eye remained stable at hand motion. Radiation-induced dry eye was managed effectively with preservative-free sodium hyaluronate eye drops. Conclusion: LINAC-based hypofractionated FSRT achieved marked local control and tumor regression in this case of a medium-large, juxtapapillary choroidal melanoma, while preserving the globe and the baseline vision. In regions without access to plaque brachytherapy, this technique offers a practical, cost-efficient, and multidisciplinary approach to eye-conserving therapy.https://paojournal.com/index.php/pjo/article/view/540juxtapapillary uveal melanomafractionated stereotactic radiotherapyocular oncologylinear accelerator therapy |
| spellingShingle | Raymund V. Tanchuling, MD Andrei P. Martin, MD Choroidal Melanoma Treated with Linear Accelerator-based Hypofractionated Stereotactic Radiotherapy: First Case of Globe Conservation in Uveal Melanoma from the Philippines Philippine Journal of Ophthalmology juxtapapillary uveal melanoma fractionated stereotactic radiotherapy ocular oncology linear accelerator therapy |
| title | Choroidal Melanoma Treated with Linear Accelerator-based Hypofractionated Stereotactic Radiotherapy: First Case of Globe Conservation in Uveal Melanoma from the Philippines |
| title_full | Choroidal Melanoma Treated with Linear Accelerator-based Hypofractionated Stereotactic Radiotherapy: First Case of Globe Conservation in Uveal Melanoma from the Philippines |
| title_fullStr | Choroidal Melanoma Treated with Linear Accelerator-based Hypofractionated Stereotactic Radiotherapy: First Case of Globe Conservation in Uveal Melanoma from the Philippines |
| title_full_unstemmed | Choroidal Melanoma Treated with Linear Accelerator-based Hypofractionated Stereotactic Radiotherapy: First Case of Globe Conservation in Uveal Melanoma from the Philippines |
| title_short | Choroidal Melanoma Treated with Linear Accelerator-based Hypofractionated Stereotactic Radiotherapy: First Case of Globe Conservation in Uveal Melanoma from the Philippines |
| title_sort | choroidal melanoma treated with linear accelerator based hypofractionated stereotactic radiotherapy first case of globe conservation in uveal melanoma from the philippines |
| topic | juxtapapillary uveal melanoma fractionated stereotactic radiotherapy ocular oncology linear accelerator therapy |
| url | https://paojournal.com/index.php/pjo/article/view/540 |
| work_keys_str_mv | AT raymundvtanchulingmd choroidalmelanomatreatedwithlinearacceleratorbasedhypofractionatedstereotacticradiotherapyfirstcaseofglobeconservationinuvealmelanomafromthephilippines AT andreipmartinmd choroidalmelanomatreatedwithlinearacceleratorbasedhypofractionatedstereotacticradiotherapyfirstcaseofglobeconservationinuvealmelanomafromthephilippines |