Pericardiectomy with routine cardiopulmonary bypass: a multicenter, randomized controlled trial
Abstract Constrictive pericarditis is a result of chronic inflammation characterized by thickening and calcification of pericardial fibers, impaired diastolic filling, reduced cardiac output, and ultimately heart failure. The main objective of this multicenter trial is to evaluate whether convention...
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BMC
2025-04-01
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| Series: | Trials |
| Online Access: | https://doi.org/10.1186/s13063-025-08843-5 |
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| author | Jing-bin Huang Chang-chao Lu Zhao-ke Wen |
| author_facet | Jing-bin Huang Chang-chao Lu Zhao-ke Wen |
| author_sort | Jing-bin Huang |
| collection | DOAJ |
| description | Abstract Constrictive pericarditis is a result of chronic inflammation characterized by thickening and calcification of pericardial fibers, impaired diastolic filling, reduced cardiac output, and ultimately heart failure. The main objective of this multicenter trial is to evaluate whether conventional extracorporeal circulation pericardial resection has a better prognosis than pericardial resection without extracorporeal circulation. This study is a multicenter, randomized controlled, evaluator blinded, parallel group study with an advantageous framework. A total of 436 participants with constrictive pericarditis will be randomly assigned to either the extracorporeal circulation pericardial resection group or the non-extracorporeal circulation pericardial clearance group in a 1:1 ratio using a computer. Incomplete pericardial detachment is associated with low cardiac output syndrome after pericardial resection. The causes of low cardiac output syndrome are related to incomplete resection of thickened pericardium, unsatisfactory relief of left ventricular compression, excessive ventricular dilation after pericardial dissection, myocardial weakness, and heart failure. The relief of left ventricular compression is crucial for the postoperative recovery of cardiac function. |
| format | Article |
| id | doaj-art-97e69f855bf44cdca656b7b9cfb67a05 |
| institution | Kabale University |
| issn | 1745-6215 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj-art-97e69f855bf44cdca656b7b9cfb67a052025-08-20T03:53:32ZengBMCTrials1745-62152025-04-0126111010.1186/s13063-025-08843-5Pericardiectomy with routine cardiopulmonary bypass: a multicenter, randomized controlled trialJing-bin Huang0Chang-chao Lu1Zhao-ke Wen2Department of Cardiothoracic Surgery, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous RegionDepartment of Cardiothoracic Surgery, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous RegionDepartment of Cardiothoracic Surgery, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous RegionAbstract Constrictive pericarditis is a result of chronic inflammation characterized by thickening and calcification of pericardial fibers, impaired diastolic filling, reduced cardiac output, and ultimately heart failure. The main objective of this multicenter trial is to evaluate whether conventional extracorporeal circulation pericardial resection has a better prognosis than pericardial resection without extracorporeal circulation. This study is a multicenter, randomized controlled, evaluator blinded, parallel group study with an advantageous framework. A total of 436 participants with constrictive pericarditis will be randomly assigned to either the extracorporeal circulation pericardial resection group or the non-extracorporeal circulation pericardial clearance group in a 1:1 ratio using a computer. Incomplete pericardial detachment is associated with low cardiac output syndrome after pericardial resection. The causes of low cardiac output syndrome are related to incomplete resection of thickened pericardium, unsatisfactory relief of left ventricular compression, excessive ventricular dilation after pericardial dissection, myocardial weakness, and heart failure. The relief of left ventricular compression is crucial for the postoperative recovery of cardiac function.https://doi.org/10.1186/s13063-025-08843-5 |
| spellingShingle | Jing-bin Huang Chang-chao Lu Zhao-ke Wen Pericardiectomy with routine cardiopulmonary bypass: a multicenter, randomized controlled trial Trials |
| title | Pericardiectomy with routine cardiopulmonary bypass: a multicenter, randomized controlled trial |
| title_full | Pericardiectomy with routine cardiopulmonary bypass: a multicenter, randomized controlled trial |
| title_fullStr | Pericardiectomy with routine cardiopulmonary bypass: a multicenter, randomized controlled trial |
| title_full_unstemmed | Pericardiectomy with routine cardiopulmonary bypass: a multicenter, randomized controlled trial |
| title_short | Pericardiectomy with routine cardiopulmonary bypass: a multicenter, randomized controlled trial |
| title_sort | pericardiectomy with routine cardiopulmonary bypass a multicenter randomized controlled trial |
| url | https://doi.org/10.1186/s13063-025-08843-5 |
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