Macrophylloflavone: A New Biflavonoid from Garcinia macrophylla Mart. (Clusiaceae) for Antibacterial, Antioxidant, and Anti-Type 2 Diabetes Mellitus Activities
Investigations of antibacterial, antioxidant, and anti-type 2 diabetes mellitus activities have been carried out on Garcinia macrophylla Mart. plant extract fractions. An isolate from a fraction of ethyl acetate extract was characterized with spectroscopic data. A new biflavonoid compound was found...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2020/2983129 |
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| author | Hawa Purnama Celala Ary Cane Nurdin Saidi Mustanir Yahya Darusman Darusman Erlidawati Erlidawati Safrida Safrida Musri Musman |
| author_facet | Hawa Purnama Celala Ary Cane Nurdin Saidi Mustanir Yahya Darusman Darusman Erlidawati Erlidawati Safrida Safrida Musri Musman |
| author_sort | Hawa Purnama Celala Ary Cane |
| collection | DOAJ |
| description | Investigations of antibacterial, antioxidant, and anti-type 2 diabetes mellitus activities have been carried out on Garcinia macrophylla Mart. plant extract fractions. An isolate from a fraction of ethyl acetate extract was characterized with spectroscopic data. A new biflavonoid compound was found to have a skeleton of 5,7,4′,5″,7″,3‴,4‴-heptahydroxyflavanone[3-6″] flavones which was named macrophylloflavone (1). The compound was evaluated for its antibacterial activity against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 with cephazolin as a positive control, antioxidant assay against 2,2 diphenyl-1-picrylhydrazyl (DPPH) with ascorbic acid as the positive control, and anti-type 2 diabetes mellitus treatment with metformin as a positive control. The biflavonoid compound exhibited a good inhibition for bacteria and free radical DPPH. Furthermore, biflavonoid compound treatment on the diabetic rats suggested its ability to decrease the blood glucose level. This study provided evidence that the plant has antibacterial, antioxidant, and antidiabetic properties. |
| format | Article |
| id | doaj-art-97e67a7e111b4fcaa814f634b8e4b545 |
| institution | DOAJ |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-97e67a7e111b4fcaa814f634b8e4b5452025-08-20T03:20:39ZengWileyThe Scientific World Journal2356-61401537-744X2020-01-01202010.1155/2020/29831292983129Macrophylloflavone: A New Biflavonoid from Garcinia macrophylla Mart. (Clusiaceae) for Antibacterial, Antioxidant, and Anti-Type 2 Diabetes Mellitus ActivitiesHawa Purnama Celala Ary Cane0Nurdin Saidi1Mustanir Yahya2Darusman Darusman3Erlidawati Erlidawati4Safrida Safrida5Musri Musman6Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaDepartment of Chemistry, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaDepartment of Chemistry, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaDepartment of Soil Science, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaDepartment of Chemistry Education, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaDepartment of Biology Education, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaDepartment of Chemistry Education, Universitas Syiah Kuala, Banda Aceh 23111, IndonesiaInvestigations of antibacterial, antioxidant, and anti-type 2 diabetes mellitus activities have been carried out on Garcinia macrophylla Mart. plant extract fractions. An isolate from a fraction of ethyl acetate extract was characterized with spectroscopic data. A new biflavonoid compound was found to have a skeleton of 5,7,4′,5″,7″,3‴,4‴-heptahydroxyflavanone[3-6″] flavones which was named macrophylloflavone (1). The compound was evaluated for its antibacterial activity against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 with cephazolin as a positive control, antioxidant assay against 2,2 diphenyl-1-picrylhydrazyl (DPPH) with ascorbic acid as the positive control, and anti-type 2 diabetes mellitus treatment with metformin as a positive control. The biflavonoid compound exhibited a good inhibition for bacteria and free radical DPPH. Furthermore, biflavonoid compound treatment on the diabetic rats suggested its ability to decrease the blood glucose level. This study provided evidence that the plant has antibacterial, antioxidant, and antidiabetic properties.http://dx.doi.org/10.1155/2020/2983129 |
| spellingShingle | Hawa Purnama Celala Ary Cane Nurdin Saidi Mustanir Yahya Darusman Darusman Erlidawati Erlidawati Safrida Safrida Musri Musman Macrophylloflavone: A New Biflavonoid from Garcinia macrophylla Mart. (Clusiaceae) for Antibacterial, Antioxidant, and Anti-Type 2 Diabetes Mellitus Activities The Scientific World Journal |
| title | Macrophylloflavone: A New Biflavonoid from Garcinia macrophylla Mart. (Clusiaceae) for Antibacterial, Antioxidant, and Anti-Type 2 Diabetes Mellitus Activities |
| title_full | Macrophylloflavone: A New Biflavonoid from Garcinia macrophylla Mart. (Clusiaceae) for Antibacterial, Antioxidant, and Anti-Type 2 Diabetes Mellitus Activities |
| title_fullStr | Macrophylloflavone: A New Biflavonoid from Garcinia macrophylla Mart. (Clusiaceae) for Antibacterial, Antioxidant, and Anti-Type 2 Diabetes Mellitus Activities |
| title_full_unstemmed | Macrophylloflavone: A New Biflavonoid from Garcinia macrophylla Mart. (Clusiaceae) for Antibacterial, Antioxidant, and Anti-Type 2 Diabetes Mellitus Activities |
| title_short | Macrophylloflavone: A New Biflavonoid from Garcinia macrophylla Mart. (Clusiaceae) for Antibacterial, Antioxidant, and Anti-Type 2 Diabetes Mellitus Activities |
| title_sort | macrophylloflavone a new biflavonoid from garcinia macrophylla mart clusiaceae for antibacterial antioxidant and anti type 2 diabetes mellitus activities |
| url | http://dx.doi.org/10.1155/2020/2983129 |
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