“Surviving and Thriving”: evidence for cortical GABA stabilization in cognitively-intact oldest-old adults

“Surviving and Thriving”: evidence for cortical GABA stabilization in cognitively-intact oldest-old adults

Abstract Age-related alterations in GABAergic function, including depletion of cortical GABA concentrations, is likely associated with declining cognitive performance in normative aging. However, the extent to which GABAergic function is perturbed in the highest-functioning stratum of the oldest-old...

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Main Authors: Mark K. Britton, Greg Jensen, Richard AE Edden, Nicolaas AJ Puts, Sara A. Nolin, Stacy Suzanne Merritt, Roxanne F. Rezaei, Megan Forbes, Keyanni Joy Johnson, Pradyumna K. Bharadwaj, Mary Kathryn Franchetti, David A. Raichlen, Cortney J. Jessup, G. Alex Hishaw, Emily J. Van Etten, Aaron T. Gudmundson, Saipavitra Murali-Manohar, Hannah Cowart, Theodore P. Trouard, David S. Geldmacher, Virginia G. Wadley, Noam Alperin, Bonnie E. Levin, Tatjana Rundek, Kristina M. Visscher, Adam J. Woods, Gene E. Alexander, Ronald A. Cohen, Eric C. Porges
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03302-w
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