Synergistic effects of Psidium guajava and copper nanoparticles reinforced hybrid Hydrogel for tissue engineering
Hydrogels are biopolymers proficient in engrossing much water in their 3D network structure. However, single-polymer hydrogels frequently experience poor physio-mechanical properties, confining their border applications. The present work concentrated on developing chemically crosslinked hydrogels us...
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KeAi Communications Co., Ltd.
2025-04-01
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| Series: | Advanced Industrial and Engineering Polymer Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542504824000423 |
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| author | D.V. Krishna M.R. Sankar P.V.G.K. Sarma E.L. Samundeshwari |
| author_facet | D.V. Krishna M.R. Sankar P.V.G.K. Sarma E.L. Samundeshwari |
| author_sort | D.V. Krishna |
| collection | DOAJ |
| description | Hydrogels are biopolymers proficient in engrossing much water in their 3D network structure. However, single-polymer hydrogels frequently experience poor physio-mechanical properties, confining their border applications. The present work concentrated on developing chemically crosslinked hydrogels using the terpolymerization of gelatin (GEL), guar gum (GGM), and polyvinyl alcohol (PVA). Ethanolic extract of Psidium guajava leaf (EPG) and copper nanoparticles (CuNPs) were added to enhance the biomechanical properties of the developed hydrogels. Hydrogels' viscoelastic, mechanical, swelling, and cytotoxicity properties were assessed. All the hydrogels exhibited a porous-like structure with a swelling index of 230–280 %. A compressive strength of 5 MPa with splendid chondrocyte viability was noticed in the hydrogels comprised of EPG and CuNPs. The multiple interactions among the polymer chains impart better frequency and shear strain-dependent behavior. The time-dependent frictional behavior of hydrogel under the lubrication of artificial synovial fluid reveals the decreased coefficient of friction over time. The performance of the hybrid hydrogel enhanced with EPG and CuNPs was superior, making it a promising material for tissue engineering applications. |
| format | Article |
| id | doaj-art-97e502309ace4e1e92ff1117d0effeaa |
| institution | OA Journals |
| issn | 2542-5048 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Advanced Industrial and Engineering Polymer Research |
| spelling | doaj-art-97e502309ace4e1e92ff1117d0effeaa2025-08-20T02:24:59ZengKeAi Communications Co., Ltd.Advanced Industrial and Engineering Polymer Research2542-50482025-04-018226427810.1016/j.aiepr.2024.10.001Synergistic effects of Psidium guajava and copper nanoparticles reinforced hybrid Hydrogel for tissue engineeringD.V. Krishna0M.R. Sankar1P.V.G.K. Sarma2E.L. Samundeshwari3Department of Mechanical Engineering, Indian Institute of Technology Tirupati, 517619, Andhra Pradesh, IndiaDepartment of Mechanical Engineering, Indian Institute of Technology Tirupati, 517619, Andhra Pradesh, India; Corresponding author.Department of Biotechnology, Sri Venkateswara Institute of Medical Sciences Tirupati, 517501, Andhra Pradesh, IndiaDepartment of Biotechnology, Sri Venkateswara Institute of Medical Sciences Tirupati, 517501, Andhra Pradesh, IndiaHydrogels are biopolymers proficient in engrossing much water in their 3D network structure. However, single-polymer hydrogels frequently experience poor physio-mechanical properties, confining their border applications. The present work concentrated on developing chemically crosslinked hydrogels using the terpolymerization of gelatin (GEL), guar gum (GGM), and polyvinyl alcohol (PVA). Ethanolic extract of Psidium guajava leaf (EPG) and copper nanoparticles (CuNPs) were added to enhance the biomechanical properties of the developed hydrogels. Hydrogels' viscoelastic, mechanical, swelling, and cytotoxicity properties were assessed. All the hydrogels exhibited a porous-like structure with a swelling index of 230–280 %. A compressive strength of 5 MPa with splendid chondrocyte viability was noticed in the hydrogels comprised of EPG and CuNPs. The multiple interactions among the polymer chains impart better frequency and shear strain-dependent behavior. The time-dependent frictional behavior of hydrogel under the lubrication of artificial synovial fluid reveals the decreased coefficient of friction over time. The performance of the hybrid hydrogel enhanced with EPG and CuNPs was superior, making it a promising material for tissue engineering applications.http://www.sciencedirect.com/science/article/pii/S2542504824000423GelatinGuava leafTissue engineeringHydrogel |
| spellingShingle | D.V. Krishna M.R. Sankar P.V.G.K. Sarma E.L. Samundeshwari Synergistic effects of Psidium guajava and copper nanoparticles reinforced hybrid Hydrogel for tissue engineering Advanced Industrial and Engineering Polymer Research Gelatin Guava leaf Tissue engineering Hydrogel |
| title | Synergistic effects of Psidium guajava and copper nanoparticles reinforced hybrid Hydrogel for tissue engineering |
| title_full | Synergistic effects of Psidium guajava and copper nanoparticles reinforced hybrid Hydrogel for tissue engineering |
| title_fullStr | Synergistic effects of Psidium guajava and copper nanoparticles reinforced hybrid Hydrogel for tissue engineering |
| title_full_unstemmed | Synergistic effects of Psidium guajava and copper nanoparticles reinforced hybrid Hydrogel for tissue engineering |
| title_short | Synergistic effects of Psidium guajava and copper nanoparticles reinforced hybrid Hydrogel for tissue engineering |
| title_sort | synergistic effects of psidium guajava and copper nanoparticles reinforced hybrid hydrogel for tissue engineering |
| topic | Gelatin Guava leaf Tissue engineering Hydrogel |
| url | http://www.sciencedirect.com/science/article/pii/S2542504824000423 |
| work_keys_str_mv | AT dvkrishna synergisticeffectsofpsidiumguajavaandcoppernanoparticlesreinforcedhybridhydrogelfortissueengineering AT mrsankar synergisticeffectsofpsidiumguajavaandcoppernanoparticlesreinforcedhybridhydrogelfortissueengineering AT pvgksarma synergisticeffectsofpsidiumguajavaandcoppernanoparticlesreinforcedhybridhydrogelfortissueengineering AT elsamundeshwari synergisticeffectsofpsidiumguajavaandcoppernanoparticlesreinforcedhybridhydrogelfortissueengineering |