Intravenous lidocaine and ketamine combined infusion in chronic pain relief: a follow-up study
Introduction: Chronic pain is a common problem worldwide. It is a significant cause of disability and is challenging to treat. Intravenous lidocaine and ketamine combined infusion is a novel treatment strategy. Data on the efficacy and acceptability of this in South Asia is sparse. We studied the s...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sri Lanka College of Internal Medicine
2025-03-01
|
| Series: | Asian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://account.ajim.sljol.info/index.php/sljo-j-ajim/article/view/257 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850037189524586496 |
|---|---|
| author | A. A. N. Samanthi S. S. Ranasinghe C. Mettananda |
| author_facet | A. A. N. Samanthi S. S. Ranasinghe C. Mettananda |
| author_sort | A. A. N. Samanthi |
| collection | DOAJ |
| description |
Introduction: Chronic pain is a common problem worldwide. It is a significant cause of disability and is challenging to treat. Intravenous lidocaine and ketamine combined infusion is a novel treatment strategy. Data on the efficacy and acceptability of this in South Asia is sparse. We studied the same in a cohort of Sri Lankans with chronic pain resistant to usual medications.
Methods: We studied all the patients with chronic pain who were not responding to routine oral analgesic medications and underwent the above treatment at the Pain Clinic of Colombo North Teaching Hospital Ragama from March to August 2022. We followed them up from the intervention date (baseline) to 1-month post-intervention at 24-hours, 2-week, and 1-month intervals. Patients were interviewed by a medical graduate using an interviewer-administered questionnaire. Data on demographics, past medical history, and pain intensity were gathered at baseline. Pain intensity was measured at baseline and 24 hours, 2 weeks, and 1 month post-intervention, while physical and psychosocial deficits were assessed at baseline and 1-month using Brief Pain Inventory Short Form (BPISF) and compared.
Results: A total of 29 patients, 8(27.6%) of them males, with a mean age (±SD) of 53±13.3 years were studied. The mean pain score at baseline, 7 ±1.5, reduced to 3 ±1.5 at 1 month (p = 0.001). The change in BPISF parameters from baseline to 1-month post-intervention were as follows: physical deficit 5±2.0 to 3±1.9(p= 0.001), sleep 6±2.3 to 3±1.9 (p= 0.001), enjoyment of life 5±2.1 to 3±1.9(p=0.001), mood 5±2.0 to 3±1.8 (p=0.001) and sexual relationship 5±2.1 to 3±1.9 (p =0.001). There were no major adverse effects of treatment. The majority, 24(80%) were satisfied with the intervention.
Conclusion: Intravenous ketamine and lidocaine combined infusion maintained sustained pain relief and improved related parameters in the majority of this Sri Lankan cohort with resistant chronic pain.
|
| format | Article |
| id | doaj-art-97e3cfc79a04466e9e2cdabfb1a08a55 |
| institution | DOAJ |
| issn | 2827-7260 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sri Lanka College of Internal Medicine |
| record_format | Article |
| series | Asian Journal of Internal Medicine |
| spelling | doaj-art-97e3cfc79a04466e9e2cdabfb1a08a552025-08-20T02:56:56ZengSri Lanka College of Internal MedicineAsian Journal of Internal Medicine2827-72602025-03-014110.4038/ajim.v4i1.257Intravenous lidocaine and ketamine combined infusion in chronic pain relief: a follow-up studyA. A. N. Samanthi0S. S. Ranasinghe1C. Mettananda2Colombo North Teaching Hospital, RagamaColombo North Teaching Hospital, RagamaUniversity of Kelaniya Introduction: Chronic pain is a common problem worldwide. It is a significant cause of disability and is challenging to treat. Intravenous lidocaine and ketamine combined infusion is a novel treatment strategy. Data on the efficacy and acceptability of this in South Asia is sparse. We studied the same in a cohort of Sri Lankans with chronic pain resistant to usual medications. Methods: We studied all the patients with chronic pain who were not responding to routine oral analgesic medications and underwent the above treatment at the Pain Clinic of Colombo North Teaching Hospital Ragama from March to August 2022. We followed them up from the intervention date (baseline) to 1-month post-intervention at 24-hours, 2-week, and 1-month intervals. Patients were interviewed by a medical graduate using an interviewer-administered questionnaire. Data on demographics, past medical history, and pain intensity were gathered at baseline. Pain intensity was measured at baseline and 24 hours, 2 weeks, and 1 month post-intervention, while physical and psychosocial deficits were assessed at baseline and 1-month using Brief Pain Inventory Short Form (BPISF) and compared. Results: A total of 29 patients, 8(27.6%) of them males, with a mean age (±SD) of 53±13.3 years were studied. The mean pain score at baseline, 7 ±1.5, reduced to 3 ±1.5 at 1 month (p = 0.001). The change in BPISF parameters from baseline to 1-month post-intervention were as follows: physical deficit 5±2.0 to 3±1.9(p= 0.001), sleep 6±2.3 to 3±1.9 (p= 0.001), enjoyment of life 5±2.1 to 3±1.9(p=0.001), mood 5±2.0 to 3±1.8 (p=0.001) and sexual relationship 5±2.1 to 3±1.9 (p =0.001). There were no major adverse effects of treatment. The majority, 24(80%) were satisfied with the intervention. Conclusion: Intravenous ketamine and lidocaine combined infusion maintained sustained pain relief and improved related parameters in the majority of this Sri Lankan cohort with resistant chronic pain. https://account.ajim.sljol.info/index.php/sljo-j-ajim/article/view/257KetamineLidocaineChronic pain reliefAnalgesiaLocal anesthetics |
| spellingShingle | A. A. N. Samanthi S. S. Ranasinghe C. Mettananda Intravenous lidocaine and ketamine combined infusion in chronic pain relief: a follow-up study Asian Journal of Internal Medicine Ketamine Lidocaine Chronic pain relief Analgesia Local anesthetics |
| title | Intravenous lidocaine and ketamine combined infusion in chronic pain relief: a follow-up study |
| title_full | Intravenous lidocaine and ketamine combined infusion in chronic pain relief: a follow-up study |
| title_fullStr | Intravenous lidocaine and ketamine combined infusion in chronic pain relief: a follow-up study |
| title_full_unstemmed | Intravenous lidocaine and ketamine combined infusion in chronic pain relief: a follow-up study |
| title_short | Intravenous lidocaine and ketamine combined infusion in chronic pain relief: a follow-up study |
| title_sort | intravenous lidocaine and ketamine combined infusion in chronic pain relief a follow up study |
| topic | Ketamine Lidocaine Chronic pain relief Analgesia Local anesthetics |
| url | https://account.ajim.sljol.info/index.php/sljo-j-ajim/article/view/257 |
| work_keys_str_mv | AT aansamanthi intravenouslidocaineandketaminecombinedinfusioninchronicpainreliefafollowupstudy AT ssranasinghe intravenouslidocaineandketaminecombinedinfusioninchronicpainreliefafollowupstudy AT cmettananda intravenouslidocaineandketaminecombinedinfusioninchronicpainreliefafollowupstudy |