A Systematic Review of Micropulse Laser Trabeculoplasty (MLT) in Primary Open-Angle Glaucoma (POAG) Management: Efficacy, Safety, and Future Perspectives
Background/Objectives: Micropulse laser trabeculoplasty (MLT) is gaining attention as a non-invasive treatment option for primary open-angle glaucoma (POAG), offering an alternative to traditional surgeries and medications. This systematic review evaluates the effectiveness, safety, and potential of...
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2025-01-01
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| author | Filippo Confalonieri Barbara Casarini Annalaura Papapicco Fabio Stiro Raffaele Piscopo Luca D’Andrea Goran Petrovski Tommaso Verdina |
| author_facet | Filippo Confalonieri Barbara Casarini Annalaura Papapicco Fabio Stiro Raffaele Piscopo Luca D’Andrea Goran Petrovski Tommaso Verdina |
| author_sort | Filippo Confalonieri |
| collection | DOAJ |
| description | Background/Objectives: Micropulse laser trabeculoplasty (MLT) is gaining attention as a non-invasive treatment option for primary open-angle glaucoma (POAG), offering an alternative to traditional surgeries and medications. This systematic review evaluates the effectiveness, safety, and potential of MLT in glaucoma management. Methods: This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The strength of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology, following the 2011 Oxford Centre for Evidence-Based Medicine (OCEBM) recommendations. Results: We identified 79 articles, and after removing duplicates and screening abstracts, 56 articles were eligible for further review. A detailed full-text analysis was conducted on 26 articles, of which 15 met the predefined inclusion criteria. Conclusions: MLT shows promise as a primary or adjunctive treatment for reducing intraocular pressure (IOP) in glaucoma and ocular hypertension patients. Current evidence supports its efficacy and safety; however, additional long-term studies are needed to confirm its durability and compare its effectiveness with traditional surgical and pharmacological approaches. Standardizing treatment protocols and refining patient selection criteria could enhance MLT’s clinical value and support its broader adoption in glaucoma care. |
| format | Article |
| id | doaj-art-97e2b0cfc7244c89ba2be0ac46548fa1 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-97e2b0cfc7244c89ba2be0ac46548fa12025-01-24T13:24:25ZengMDPI AGBiomedicines2227-90592025-01-0113121110.3390/biomedicines13010211A Systematic Review of Micropulse Laser Trabeculoplasty (MLT) in Primary Open-Angle Glaucoma (POAG) Management: Efficacy, Safety, and Future PerspectivesFilippo Confalonieri0Barbara Casarini1Annalaura Papapicco2Fabio Stiro3Raffaele Piscopo4Luca D’Andrea5Goran Petrovski6Tommaso Verdina7Department of Ophthalmology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyInstitute of Ophthalmology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, 41122 Modena, ItalyInstitute of Ophthalmology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, 41122 Modena, ItalyEye Unit, Vimercate Hospital, 20871 Vimercate, ItalyEye Clinic, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Via Pansini n. 5, 80131 Naples, ItalyEye Clinic, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Via Pansini n. 5, 80131 Naples, ItalyCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Institute for Clinical Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, NorwayInstitute of Ophthalmology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, 41122 Modena, ItalyBackground/Objectives: Micropulse laser trabeculoplasty (MLT) is gaining attention as a non-invasive treatment option for primary open-angle glaucoma (POAG), offering an alternative to traditional surgeries and medications. This systematic review evaluates the effectiveness, safety, and potential of MLT in glaucoma management. Methods: This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The strength of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology, following the 2011 Oxford Centre for Evidence-Based Medicine (OCEBM) recommendations. Results: We identified 79 articles, and after removing duplicates and screening abstracts, 56 articles were eligible for further review. A detailed full-text analysis was conducted on 26 articles, of which 15 met the predefined inclusion criteria. Conclusions: MLT shows promise as a primary or adjunctive treatment for reducing intraocular pressure (IOP) in glaucoma and ocular hypertension patients. Current evidence supports its efficacy and safety; however, additional long-term studies are needed to confirm its durability and compare its effectiveness with traditional surgical and pharmacological approaches. Standardizing treatment protocols and refining patient selection criteria could enhance MLT’s clinical value and support its broader adoption in glaucoma care.https://www.mdpi.com/2227-9059/13/1/211glaucomamicropulse laser trabeculoplasty (MLT)minimally invasive glaucoma surgeryminimally invasive bleb surgerynon-platebleb-forming glaucoma devices |
| spellingShingle | Filippo Confalonieri Barbara Casarini Annalaura Papapicco Fabio Stiro Raffaele Piscopo Luca D’Andrea Goran Petrovski Tommaso Verdina A Systematic Review of Micropulse Laser Trabeculoplasty (MLT) in Primary Open-Angle Glaucoma (POAG) Management: Efficacy, Safety, and Future Perspectives Biomedicines glaucoma micropulse laser trabeculoplasty (MLT) minimally invasive glaucoma surgery minimally invasive bleb surgery non-plate bleb-forming glaucoma devices |
| title | A Systematic Review of Micropulse Laser Trabeculoplasty (MLT) in Primary Open-Angle Glaucoma (POAG) Management: Efficacy, Safety, and Future Perspectives |
| title_full | A Systematic Review of Micropulse Laser Trabeculoplasty (MLT) in Primary Open-Angle Glaucoma (POAG) Management: Efficacy, Safety, and Future Perspectives |
| title_fullStr | A Systematic Review of Micropulse Laser Trabeculoplasty (MLT) in Primary Open-Angle Glaucoma (POAG) Management: Efficacy, Safety, and Future Perspectives |
| title_full_unstemmed | A Systematic Review of Micropulse Laser Trabeculoplasty (MLT) in Primary Open-Angle Glaucoma (POAG) Management: Efficacy, Safety, and Future Perspectives |
| title_short | A Systematic Review of Micropulse Laser Trabeculoplasty (MLT) in Primary Open-Angle Glaucoma (POAG) Management: Efficacy, Safety, and Future Perspectives |
| title_sort | systematic review of micropulse laser trabeculoplasty mlt in primary open angle glaucoma poag management efficacy safety and future perspectives |
| topic | glaucoma micropulse laser trabeculoplasty (MLT) minimally invasive glaucoma surgery minimally invasive bleb surgery non-plate bleb-forming glaucoma devices |
| url | https://www.mdpi.com/2227-9059/13/1/211 |
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