Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues
The expression of somatostatin receptor subtypes (SSTRs) in pituitary growth hormone- (GH-) secreting adenomas may predict the response to somatostatin analogues (SSA). Our aim was to evaluate the value of the immunohistochemical (IHC) scores of 2 subtypes, SSTR2 and SSTR5, in predicting the short-t...
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| Format: | Article |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/9606985 |
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| author | Wenjuan Liu Lina Xie Min He Ming Shen Jingjing Zhu Yeping Yang Meng Wang Ji Hu Hongying Ye Yiming Li Yao Zhao Zhaoyun Zhang |
| author_facet | Wenjuan Liu Lina Xie Min He Ming Shen Jingjing Zhu Yeping Yang Meng Wang Ji Hu Hongying Ye Yiming Li Yao Zhao Zhaoyun Zhang |
| author_sort | Wenjuan Liu |
| collection | DOAJ |
| description | The expression of somatostatin receptor subtypes (SSTRs) in pituitary growth hormone- (GH-) secreting adenomas may predict the response to somatostatin analogues (SSA). Our aim was to evaluate the value of the immunohistochemical (IHC) scores of 2 subtypes, SSTR2 and SSTR5, in predicting the short-term efficacy of SSA therapy in patients with active acromegaly. Ninety-three newly diagnosed acromegalic patients were included in our study. These patients were categorized into either a SSA-pretreated group (SA, n=63) or a direct-surgery group (DS, n=30), depending on whether or not presurgical SSA treatment was received. IHC analysis, using a 12-grade scoring system, with rabbit monoclonal antibodies against SSTR2 and SSTR5, was performed on all adenoma tissues. The reduction of GH, IGF-1, and tumor size after treatment with SSA for 3 months was measured. Compared with that in the DS group, SSTR2 expression was lower in the SA group. Additionally, in the SA group, SSTR2 expression was positively correlated with the reduction of IGF-1 and tumor volume. However, there was no correlation between the SSTR5 score and the efficacy of SSA. In conclusion, the protein expression of SSTR2, but not of SSTR5, is a valuable indicator in predicting biochemical and tumor size response to short-term SSA treatment in acromegalic patients. |
| format | Article |
| id | doaj-art-97e067f1cbe54edeada4cf19f61c73bb |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-97e067f1cbe54edeada4cf19f61c73bb2025-08-20T02:10:07ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/96069859606985Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin AnaloguesWenjuan Liu0Lina Xie1Min He2Ming Shen3Jingjing Zhu4Yeping Yang5Meng Wang6Ji Hu7Hongying Ye8Yiming Li9Yao Zhao10Zhaoyun Zhang11Division of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Endocrinology, Kunshan Rehabilitation Hospital, Suzhou, Jiangsu 215314, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Endocrinology, The Second Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215004, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, ChinaThe expression of somatostatin receptor subtypes (SSTRs) in pituitary growth hormone- (GH-) secreting adenomas may predict the response to somatostatin analogues (SSA). Our aim was to evaluate the value of the immunohistochemical (IHC) scores of 2 subtypes, SSTR2 and SSTR5, in predicting the short-term efficacy of SSA therapy in patients with active acromegaly. Ninety-three newly diagnosed acromegalic patients were included in our study. These patients were categorized into either a SSA-pretreated group (SA, n=63) or a direct-surgery group (DS, n=30), depending on whether or not presurgical SSA treatment was received. IHC analysis, using a 12-grade scoring system, with rabbit monoclonal antibodies against SSTR2 and SSTR5, was performed on all adenoma tissues. The reduction of GH, IGF-1, and tumor size after treatment with SSA for 3 months was measured. Compared with that in the DS group, SSTR2 expression was lower in the SA group. Additionally, in the SA group, SSTR2 expression was positively correlated with the reduction of IGF-1 and tumor volume. However, there was no correlation between the SSTR5 score and the efficacy of SSA. In conclusion, the protein expression of SSTR2, but not of SSTR5, is a valuable indicator in predicting biochemical and tumor size response to short-term SSA treatment in acromegalic patients.http://dx.doi.org/10.1155/2017/9606985 |
| spellingShingle | Wenjuan Liu Lina Xie Min He Ming Shen Jingjing Zhu Yeping Yang Meng Wang Ji Hu Hongying Ye Yiming Li Yao Zhao Zhaoyun Zhang Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues International Journal of Endocrinology |
| title | Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues |
| title_full | Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues |
| title_fullStr | Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues |
| title_full_unstemmed | Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues |
| title_short | Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues |
| title_sort | expression of somatostatin receptor 2 in somatotropinoma correlated with the short term efficacy of somatostatin analogues |
| url | http://dx.doi.org/10.1155/2017/9606985 |
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