Test-retest properties of [11C]PXT012253 as a positron emission tomography (PET) radiotracer in healthy human brain: PET imaging of mGlu4

Test-retest properties of [11C]PXT012253 as a positron emission tomography (PET) radiotracer in healthy human brain: PET imaging of mGlu4

Abstract Background The metabotropic glutamate receptor 4 (mGlu4) has been proposed as a target for Parkinson’s disease to measure levodopa-induced dyskinesia. [11C]PXT012253 is a PET radioligand for mGlu4 (3.4 nM), previously characterized in non-human primates. We aimed to determine the optimal me...

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Main Authors: Per Stenkrona, Ryosuke Arakawa, Jiamei Guo, Benny Bang-Andersen, Sangram Nag, Mohammad Mahdi Moein, Zhisheng Jia, Zsolt Cselenyi, Christer Halldin, Andrea Varrone
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:EJNMMI Research
Subjects:
Positron emission tomography (PET)
Test-retest
Human brain
[11C]PXT012253
mGlu4
Online Access:https://doi.org/10.1186/s13550-025-01266-y
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https://doi.org/10.1186/s13550-025-01266-y

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