GENETIC PREDICTORS OF ATRIAL FIBRILLATION
Atrial fibrillation (AF) is the most common heart rhythm disturbance. It is believed that the primary form of AF is genetically determined in most cases, but the genetic component cannot be excluded in the secondary form of AF. AF is a heterogeneous disease and many authors proved its relationship w...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Столичная издательская компания
2016-06-01
|
| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/1278 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849227740662726656 |
|---|---|
| author | A. V. Kuskaeva S. Yu. Nikulina A. A. Chernova N. V. Aksyutina |
| author_facet | A. V. Kuskaeva S. Yu. Nikulina A. A. Chernova N. V. Aksyutina |
| author_sort | A. V. Kuskaeva |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is the most common heart rhythm disturbance. It is believed that the primary form of AF is genetically determined in most cases, but the genetic component cannot be excluded in the secondary form of AF. AF is a heterogeneous disease and many authors proved its relationship with other genetic heart disease. In most cases, certain combinations of polymorphisms of different genes promote the development of AF. The study of genes of renin-angiotensin-aldosterone system (RAAS) is especially important, because the role of this system in AF pathogenesis is currently studding most intensively. These studies are of great practical interest, as associative effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the prevention of AF is revealed. RAAS blockers are able not only to reduce the risk of new-onset AF in hypertensive and normotensive patients but also prevent recurrence of AF. Furthermore, experimental studies showed that RAAS blockers prevent not only the remodeling of the left ventricle, and also the left atrium, pointing to the pathogenesis of AF. So, screening for susceptibility genes and the study of their polymorphism is currently an important focus in the study of AF. |
| format | Article |
| id | doaj-art-97dbcf2b34114fe5b1eccaeab11ed76b |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-97dbcf2b34114fe5b1eccaeab11ed76b2025-08-23T10:00:27ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-06-0112333133610.20996/1819-6446-2016-12-3-331-3361226GENETIC PREDICTORS OF ATRIAL FIBRILLATIONA. V. Kuskaeva0S. Yu. Nikulina1A. A. Chernova2N. V. Aksyutina3Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 RussiaKrasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 RussiaKrasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 RussiaKrasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 RussiaAtrial fibrillation (AF) is the most common heart rhythm disturbance. It is believed that the primary form of AF is genetically determined in most cases, but the genetic component cannot be excluded in the secondary form of AF. AF is a heterogeneous disease and many authors proved its relationship with other genetic heart disease. In most cases, certain combinations of polymorphisms of different genes promote the development of AF. The study of genes of renin-angiotensin-aldosterone system (RAAS) is especially important, because the role of this system in AF pathogenesis is currently studding most intensively. These studies are of great practical interest, as associative effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the prevention of AF is revealed. RAAS blockers are able not only to reduce the risk of new-onset AF in hypertensive and normotensive patients but also prevent recurrence of AF. Furthermore, experimental studies showed that RAAS blockers prevent not only the remodeling of the left ventricle, and also the left atrium, pointing to the pathogenesis of AF. So, screening for susceptibility genes and the study of their polymorphism is currently an important focus in the study of AF.https://www.rpcardio.online/jour/article/view/1278atrial fibrillationcandidate generenin-angiotensin-aldosterone systemace gene i/d polymorphismsagtr1 gene a1166c polymorphismagt gene т174м and м235т polymorphisms |
| spellingShingle | A. V. Kuskaeva S. Yu. Nikulina A. A. Chernova N. V. Aksyutina GENETIC PREDICTORS OF ATRIAL FIBRILLATION Рациональная фармакотерапия в кардиологии atrial fibrillation candidate gene renin-angiotensin-aldosterone system ace gene i/d polymorphisms agtr1 gene a1166c polymorphism agt gene т174м and м235т polymorphisms |
| title | GENETIC PREDICTORS OF ATRIAL FIBRILLATION |
| title_full | GENETIC PREDICTORS OF ATRIAL FIBRILLATION |
| title_fullStr | GENETIC PREDICTORS OF ATRIAL FIBRILLATION |
| title_full_unstemmed | GENETIC PREDICTORS OF ATRIAL FIBRILLATION |
| title_short | GENETIC PREDICTORS OF ATRIAL FIBRILLATION |
| title_sort | genetic predictors of atrial fibrillation |
| topic | atrial fibrillation candidate gene renin-angiotensin-aldosterone system ace gene i/d polymorphisms agtr1 gene a1166c polymorphism agt gene т174м and м235т polymorphisms |
| url | https://www.rpcardio.online/jour/article/view/1278 |
| work_keys_str_mv | AT avkuskaeva geneticpredictorsofatrialfibrillation AT syunikulina geneticpredictorsofatrialfibrillation AT aachernova geneticpredictorsofatrialfibrillation AT nvaksyutina geneticpredictorsofatrialfibrillation |