Restriction of Ku translocation protects telomere ends

Restriction of Ku translocation protects telomere ends

Abstract Safeguarding chromosome ends against fusions via nonhomologous end joining (NHEJ) is essential for genome integrity. Paradoxically, the conserved NHEJ core factor Ku binds telomere ends. How it is prevented from promoting NHEJ remains unclear, as does the mechanism that allows Ku to coexist...

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Main Authors: Stefano Mattarocci, Sonia Baconnais, Florian Roisné-Hamelin, Sabrina Pobiega, Olivier Alibert, Vincent Morin, Alice Deshayes, Xavier Veaute, Virginie Ropars, Maelenn Chevreuil, Johannes Mehringer, Didier Busso, Gerard Mazon, Paloma Fernandez Varela, Éric Le Cam, Jean-Baptiste Charbonnier, Philippe Cuniasse, Stéphane Marcand
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61864-1
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