THE ROLE OF EPITHELIAL-TO-MESENCHYMAL TRANSITION AND AUTOPHAGY IN ANTITUMORAL RESPONSE OF MELANOMA CELL LINES TO TARGET INHIBITION OF MEK AND mTOR KINASES

THE ROLE OF EPITHELIAL-TO-MESENCHYMAL TRANSITION AND AUTOPHAGY IN ANTITUMORAL RESPONSE OF MELANOMA CELL LINES TO TARGET INHIBITION OF MEK AND mTOR KINASES

Introduction. Cutaneous melanoma is a challenge to treat due to rapid progression of disease and acquired resistance to therapy. Autophagy and the epithelial-to-mesenchymal transition (EMT) are closely interrelated and play a key role in tumor progression. Targeted co-inhibition of MEK and mTOR kina...

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Bibliographic Details
Main Authors: A. S. Lozhkomoev, O. V. Bakina, A. N. Fomenko, A. V. Avgustinovich, S. G. Afanasyev, A. Yu. Dobrodeev, L. V. Spirina, A. S. Tarasova, U. B. Urmonov
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2019-06-01
Series:Сибирский онкологический журнал
Subjects:
melanoma. autophagy
epithelial-to-mesenchymal transition
3d spheroids
experimental therapy
Online Access:https://www.siboncoj.ru/jour/article/view/1097
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