Oral supplementation with propionate is reflected in the serum of healthy individuals
Background: Short-chain fatty acids (SCFAs), including propionic acid (PA), are key in immunological research. Supplementing PA has shown benefits for autoimmune diseases. A comprehensive understanding of the PA pharmacokinetics is essential for the optimal design and execution of studies utilizing...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Therapeutic Advances in Neurological Disorders |
| Online Access: | https://doi.org/10.1177/17562864241309755 |
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| author | Maximilian Schröder Arijan Pasic Frank Hirche Svitlana Rozanova Melissa Sgodzai Barbara Gisevius Lea Horstkemper Ralf Gold Katrin Marcus Kalliopi Pitarokoili Jeremias Motte Katalin Barkovits Gabriele Stangl Anna Lena Fisse |
| author_facet | Maximilian Schröder Arijan Pasic Frank Hirche Svitlana Rozanova Melissa Sgodzai Barbara Gisevius Lea Horstkemper Ralf Gold Katrin Marcus Kalliopi Pitarokoili Jeremias Motte Katalin Barkovits Gabriele Stangl Anna Lena Fisse |
| author_sort | Maximilian Schröder |
| collection | DOAJ |
| description | Background: Short-chain fatty acids (SCFAs), including propionic acid (PA), are key in immunological research. Supplementing PA has shown benefits for autoimmune diseases. A comprehensive understanding of the PA pharmacokinetics is essential for the optimal design and execution of studies utilizing orally administered PA. Objective: We propose two methods of measuring PA in serum, carried out by different laboratories. Design: Blood samples from 20 volunteers were collected hourly following PA supplementation. Methods: Serum propionate quantification was performed with two independent mass spectrometry-based (MS) analyses, including liquid-chromatography (LC)-MS and direct-infusion (DI)-MS. Results: PA levels increased within 1 h of ingestion of 500 mg PA. Serum concentrations ranged from 1.3 to 4.5 µmol/L, rising significantly after 1 h ( p < 0.05). Serum levels returned to baseline within 2 h. No significant differences were found regarding sex or diet. Conclusion: The shown pharmacokinetics can be used in future PA research. |
| format | Article |
| id | doaj-art-97d413a424b54547a9ff245500cc700b |
| institution | Kabale University |
| issn | 1756-2864 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Neurological Disorders |
| spelling | doaj-art-97d413a424b54547a9ff245500cc700b2025-01-23T15:04:01ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28642025-01-011810.1177/17562864241309755Oral supplementation with propionate is reflected in the serum of healthy individualsMaximilian SchröderArijan PasicFrank HircheSvitlana RozanovaMelissa SgodzaiBarbara GiseviusLea HorstkemperRalf GoldKatrin MarcusKalliopi PitarokoiliJeremias MotteKatalin BarkovitsGabriele StanglAnna Lena FisseBackground: Short-chain fatty acids (SCFAs), including propionic acid (PA), are key in immunological research. Supplementing PA has shown benefits for autoimmune diseases. A comprehensive understanding of the PA pharmacokinetics is essential for the optimal design and execution of studies utilizing orally administered PA. Objective: We propose two methods of measuring PA in serum, carried out by different laboratories. Design: Blood samples from 20 volunteers were collected hourly following PA supplementation. Methods: Serum propionate quantification was performed with two independent mass spectrometry-based (MS) analyses, including liquid-chromatography (LC)-MS and direct-infusion (DI)-MS. Results: PA levels increased within 1 h of ingestion of 500 mg PA. Serum concentrations ranged from 1.3 to 4.5 µmol/L, rising significantly after 1 h ( p < 0.05). Serum levels returned to baseline within 2 h. No significant differences were found regarding sex or diet. Conclusion: The shown pharmacokinetics can be used in future PA research.https://doi.org/10.1177/17562864241309755 |
| spellingShingle | Maximilian Schröder Arijan Pasic Frank Hirche Svitlana Rozanova Melissa Sgodzai Barbara Gisevius Lea Horstkemper Ralf Gold Katrin Marcus Kalliopi Pitarokoili Jeremias Motte Katalin Barkovits Gabriele Stangl Anna Lena Fisse Oral supplementation with propionate is reflected in the serum of healthy individuals Therapeutic Advances in Neurological Disorders |
| title | Oral supplementation with propionate is reflected in the serum of healthy individuals |
| title_full | Oral supplementation with propionate is reflected in the serum of healthy individuals |
| title_fullStr | Oral supplementation with propionate is reflected in the serum of healthy individuals |
| title_full_unstemmed | Oral supplementation with propionate is reflected in the serum of healthy individuals |
| title_short | Oral supplementation with propionate is reflected in the serum of healthy individuals |
| title_sort | oral supplementation with propionate is reflected in the serum of healthy individuals |
| url | https://doi.org/10.1177/17562864241309755 |
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