Aggravation of symptomatic occipital epilepsy of childhood by carbamazepine
Introduction. Carbamazepine can lead to aggravation of epileptic seizures in generalized epilepsies (primary or secondary) with clinical manifestations of absence (typical or atypical) and/or myoclonic seizures. However, some focal epilepsies can be also aggravated by the introduction of ca...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2014-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501404404S.pdf |
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| Summary: | Introduction. Carbamazepine can lead to aggravation of epileptic seizures in
generalized epilepsies (primary or secondary) with clinical manifestations of
absence (typical or atypical) and/or myoclonic seizures. However, some focal
epilepsies can be also aggravated by the introduction of carbamazepine. Case
report. We presented a 10-year-old boy born after a complicated and prolonged
delivery completed by vacuum extraction, of early psychomotor development
within normal limits. At the age of 8 years he had the first epileptic
seizure of simple occipital type with generalization and urination. Brain
magnetic resonance imaging (MRI) showed focal cortical reductions in the left
parietal and occipital regions. Interictal EEG recorded slowed basic
activities above the posterior regions of the left hemisphere, with
intermittent occurrence of occipital sharp waves and bioccipital sharp and
slow-wave complexes. Initially, treatment with valproate was administered;
however, the addition of carbamazepine into therapy induced aggravation of
seizures and EEG findings, changed behavior and poor performance at school.
By withdrawal of carbamazepine the condition improved both clinically and in
EEG findings. Conclusion. Childhood occipital epilepsy lesions show
deterioration due to carbamazepine, which if administered induces aggravation
of seizures, behavior changes, cognition with occurrence of long-term
bilateral discharges, and posterior sharp and slow wave high amplitude
complexes recorded by EEG. |
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| ISSN: | 0042-8450 |