Paraquat-associated Severe Acute Kidney Injury—Study from India
To analyze the outcomes of severe acute kidney injury in patients with paraquat ingestion. This retrospective analysis of case records was done in our institute, a tertiary care government teaching hospital, over a period of 4 years. Of the total 1310 acute paraquat poisonings during this period, s...
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| Format: | Article |
| Language: | English |
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Troika Publisher
2022-12-01
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| Series: | Journal of Renal and Hepatic Disorders |
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| Online Access: | http://mail.jrenhep.com/index.php/jrenhep/article/view/140 |
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| author | Manjusha Yadla K. Manu K.V. Anupama B. Rajasekhar |
| author_facet | Manjusha Yadla K. Manu K.V. Anupama B. Rajasekhar |
| author_sort | Manjusha Yadla |
| collection | DOAJ |
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To analyze the outcomes of severe acute kidney injury in patients with paraquat ingestion. This retrospective analysis of case records was done in our institute, a tertiary care government teaching hospital, over a period of 4 years. Of the total 1310 acute paraquat poisonings during this period, severe acute kidney injury (AKI), referred for nephrology management was observed in 60 patients. Common symptoms at presentation include vomiting, oral ulcers, and abdominal pain. Oliguric AKI was present in 26%. Need for renal replacement therapy was observed in 95% of the cases. Mortality was observed in 38 of the 60 patients (68%). Factors associated with mortality on Cox regression analysis include amount of consumption. Estimated duration of survival on analysis curves was 8 days in 50% after admission and 15 days after consumption in 50%. Paraquat poisoning is associated with grave outcomes of morbidity and mortality. Severity of AKI is significant in this poisoning. Amount of consumption, latency of referral play a major role in outcomes.
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| format | Article |
| id | doaj-art-97cc96818a4e43b38ba545c822ff3e38 |
| institution | Kabale University |
| issn | 2207-3744 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Troika Publisher |
| record_format | Article |
| series | Journal of Renal and Hepatic Disorders |
| spelling | doaj-art-97cc96818a4e43b38ba545c822ff3e382025-08-20T03:56:55ZengTroika PublisherJournal of Renal and Hepatic Disorders2207-37442022-12-016210.15586/jrenhep.v6i2.140Paraquat-associated Severe Acute Kidney Injury—Study from IndiaManjusha Yadla0K. Manu1K.V. Anupama2B. Rajasekhar3Department of Nephrology, Gandhi Medical College, Hyderabad, Telangana, India.Department of Nephrology, Gandhi Medical College, Hyderabad, Telangana, India.Department of Nephrology, Gandhi Medical College, Hyderabad, Telangana, India.Department of Nephrology, Gandhi Medical College, Hyderabad, Telangana, India. To analyze the outcomes of severe acute kidney injury in patients with paraquat ingestion. This retrospective analysis of case records was done in our institute, a tertiary care government teaching hospital, over a period of 4 years. Of the total 1310 acute paraquat poisonings during this period, severe acute kidney injury (AKI), referred for nephrology management was observed in 60 patients. Common symptoms at presentation include vomiting, oral ulcers, and abdominal pain. Oliguric AKI was present in 26%. Need for renal replacement therapy was observed in 95% of the cases. Mortality was observed in 38 of the 60 patients (68%). Factors associated with mortality on Cox regression analysis include amount of consumption. Estimated duration of survival on analysis curves was 8 days in 50% after admission and 15 days after consumption in 50%. Paraquat poisoning is associated with grave outcomes of morbidity and mortality. Severity of AKI is significant in this poisoning. Amount of consumption, latency of referral play a major role in outcomes. http://mail.jrenhep.com/index.php/jrenhep/article/view/140severe acute kidney injuryparaquat ingestionpoisoningrenal replacement therapy |
| spellingShingle | Manjusha Yadla K. Manu K.V. Anupama B. Rajasekhar Paraquat-associated Severe Acute Kidney Injury—Study from India Journal of Renal and Hepatic Disorders severe acute kidney injury paraquat ingestion poisoning renal replacement therapy |
| title | Paraquat-associated Severe Acute Kidney Injury—Study from India |
| title_full | Paraquat-associated Severe Acute Kidney Injury—Study from India |
| title_fullStr | Paraquat-associated Severe Acute Kidney Injury—Study from India |
| title_full_unstemmed | Paraquat-associated Severe Acute Kidney Injury—Study from India |
| title_short | Paraquat-associated Severe Acute Kidney Injury—Study from India |
| title_sort | paraquat associated severe acute kidney injury study from india |
| topic | severe acute kidney injury paraquat ingestion poisoning renal replacement therapy |
| url | http://mail.jrenhep.com/index.php/jrenhep/article/view/140 |
| work_keys_str_mv | AT manjushayadla paraquatassociatedsevereacutekidneyinjurystudyfromindia AT kmanu paraquatassociatedsevereacutekidneyinjurystudyfromindia AT kvanupama paraquatassociatedsevereacutekidneyinjurystudyfromindia AT brajasekhar paraquatassociatedsevereacutekidneyinjurystudyfromindia |