Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection
Abstract. Infection and vaccination can provide protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence of SARS-CoV-2 variants has persisted, leading to breakthrough infections. Owing to the original antigenic sin (OAS), variant breakthrough i...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health - Lippincott Williams Wilkins
2024-07-01
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| Series: | Infectious Diseases & Immunity |
| Online Access: | http://journals.lww.com/10.1097/ID9.0000000000000125 |
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| author | Miao Wang Huimin Guo Bin Ju Zheng Zhang Haijuan Wang |
| author_facet | Miao Wang Huimin Guo Bin Ju Zheng Zhang Haijuan Wang |
| author_sort | Miao Wang |
| collection | DOAJ |
| description | Abstract. Infection and vaccination can provide protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence of SARS-CoV-2 variants has persisted, leading to breakthrough infections. Owing to the original antigenic sin (OAS), variant breakthrough infection or vaccination potentially induces a stronger antibody response against the ancestral strain than to subsequent variants, as in the case of influenza. Thus, overcoming OAS is important for the development of future vaccine designs. This review summarizes the recent findings on OAS in the antibody response to SARS-CoV-2 and its variants, with an emphasis on future vaccine designs. |
| format | Article |
| id | doaj-art-97c723e92ccb422cbdf7a7ece13ded46 |
| institution | OA Journals |
| issn | 2096-9511 2693-8839 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Wolters Kluwer Health - Lippincott Williams Wilkins |
| record_format | Article |
| series | Infectious Diseases & Immunity |
| spelling | doaj-art-97c723e92ccb422cbdf7a7ece13ded462025-08-20T02:09:55ZengWolters Kluwer Health - Lippincott Williams WilkinsInfectious Diseases & Immunity2096-95112693-88392024-07-014313213710.1097/ID9.0000000000000125202407000-00005Original Antigenic Sin on Antibody Response in SARS-CoV-2 InfectionMiao Wang0Huimin Guo1Bin Ju2Zheng Zhang3Haijuan Wang1 Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China1 Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China1 Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China1 Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, ChinaAbstract. Infection and vaccination can provide protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence of SARS-CoV-2 variants has persisted, leading to breakthrough infections. Owing to the original antigenic sin (OAS), variant breakthrough infection or vaccination potentially induces a stronger antibody response against the ancestral strain than to subsequent variants, as in the case of influenza. Thus, overcoming OAS is important for the development of future vaccine designs. This review summarizes the recent findings on OAS in the antibody response to SARS-CoV-2 and its variants, with an emphasis on future vaccine designs.http://journals.lww.com/10.1097/ID9.0000000000000125 |
| spellingShingle | Miao Wang Huimin Guo Bin Ju Zheng Zhang Haijuan Wang Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection Infectious Diseases & Immunity |
| title | Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection |
| title_full | Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection |
| title_fullStr | Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection |
| title_full_unstemmed | Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection |
| title_short | Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection |
| title_sort | original antigenic sin on antibody response in sars cov 2 infection |
| url | http://journals.lww.com/10.1097/ID9.0000000000000125 |
| work_keys_str_mv | AT miaowang originalantigenicsinonantibodyresponseinsarscov2infection AT huiminguo originalantigenicsinonantibodyresponseinsarscov2infection AT binju originalantigenicsinonantibodyresponseinsarscov2infection AT zhengzhang originalantigenicsinonantibodyresponseinsarscov2infection AT haijuanwang originalantigenicsinonantibodyresponseinsarscov2infection |