Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA
Long non-coding RNAs (lncRNAs) interact with a variety of biomolecules, including DNA, mRNAs, microRNA, and proteins, to regulate various cellular processes. Recently, their interactions with lipids have gained increasing attention as an emerging research area. Both lipids and lncRNAs play central r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/15/1193 |
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| author | Andrea Bayona-Hernandez Ana Miladinović Ludovica Antiga Pavel Hozak Martin Sztacho Enrique Castano |
| author_facet | Andrea Bayona-Hernandez Ana Miladinović Ludovica Antiga Pavel Hozak Martin Sztacho Enrique Castano |
| author_sort | Andrea Bayona-Hernandez |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) interact with a variety of biomolecules, including DNA, mRNAs, microRNA, and proteins, to regulate various cellular processes. Recently, their interactions with lipids have gained increasing attention as an emerging research area. Both lipids and lncRNAs play central roles in cellular regulation, and growing evidence reveals a complex interplay between these molecules. These interactions contribute to key biological functions, such as cancer progression, lipid droplet transport, autophagy, liquid−liquid phase separation, and the formation of organelles without membranes. Understanding the lipid−lncRNA interface opens new avenues for unraveling cellular regulation and disease mechanisms, holding great potential not only for elucidating the fundamental aspects of cellular biology but also for identifying innovative therapeutic targets for metabolic disorders and cancer. This review highlights the biological relevance of lipid–lncRNA interactions by exploring their roles in cellular organization, regulation, and diseases, including metabolic and cancer-related disorders. |
| format | Article |
| id | doaj-art-97c6e64af2494eefb30f8d63688ea9da |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-97c6e64af2494eefb30f8d63688ea9da2025-08-20T03:35:58ZengMDPI AGCells2073-44092025-08-011415119310.3390/cells14151193Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNAAndrea Bayona-Hernandez0Ana Miladinović1Ludovica Antiga2Pavel Hozak3Martin Sztacho4Enrique Castano5Unidad de Biologia Integrativa, Centro de Investigación Científica de Yucatán, A.C., Mérida 97205, Yucatan, MexicoDepartment of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech RepublicDepartment of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech RepublicDepartment of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech RepublicLaboratory of Cancer Cell Architecture, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, 128 00 Prague, Czech RepublicUnidad de Biologia Integrativa, Centro de Investigación Científica de Yucatán, A.C., Mérida 97205, Yucatan, MexicoLong non-coding RNAs (lncRNAs) interact with a variety of biomolecules, including DNA, mRNAs, microRNA, and proteins, to regulate various cellular processes. Recently, their interactions with lipids have gained increasing attention as an emerging research area. Both lipids and lncRNAs play central roles in cellular regulation, and growing evidence reveals a complex interplay between these molecules. These interactions contribute to key biological functions, such as cancer progression, lipid droplet transport, autophagy, liquid−liquid phase separation, and the formation of organelles without membranes. Understanding the lipid−lncRNA interface opens new avenues for unraveling cellular regulation and disease mechanisms, holding great potential not only for elucidating the fundamental aspects of cellular biology but also for identifying innovative therapeutic targets for metabolic disorders and cancer. This review highlights the biological relevance of lipid–lncRNA interactions by exploring their roles in cellular organization, regulation, and diseases, including metabolic and cancer-related disorders.https://www.mdpi.com/2073-4409/14/15/1193lncRNAphospholipidsphase separation |
| spellingShingle | Andrea Bayona-Hernandez Ana Miladinović Ludovica Antiga Pavel Hozak Martin Sztacho Enrique Castano Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA Cells lncRNA phospholipids phase separation |
| title | Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA |
| title_full | Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA |
| title_fullStr | Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA |
| title_full_unstemmed | Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA |
| title_short | Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA |
| title_sort | lipid lncrna crossroads an overview of interactions between lipids and lncrna |
| topic | lncRNA phospholipids phase separation |
| url | https://www.mdpi.com/2073-4409/14/15/1193 |
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