Synthesis, Structural, Morphological Characterization, and Cytotoxicity Assays of Metal Complexes Decorated SiO2 Nanoparticles Against Breast Cancer Cell Lines (MDA-MB-231)
This study examines the new synthesis of Pt (IV) and Au (III) Mannich base complexes derived from ciprofloxacin. The complexes were then used as precursors to prepare SiO2/PtO2 and SiO2/Au2O3 nanoparticles by depositing the synthesized complexes on porous silica nanoparticles. Elemental analysis, F...
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University of Baghdad, College of Science for Women
2024-08-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8834 |
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| author | Alya'a J. Ahmed Mahasin F. Alias |
| author_facet | Alya'a J. Ahmed Mahasin F. Alias |
| author_sort | Alya'a J. Ahmed |
| collection | DOAJ |
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This study examines the new synthesis of Pt (IV) and Au (III) Mannich base complexes derived from ciprofloxacin. The complexes were then used as precursors to prepare SiO2/PtO2 and SiO2/Au2O3 nanoparticles by depositing the synthesized complexes on porous silica nanoparticles. Elemental analysis, FT-IR, UV-vis, molar conductivity measurements, and melting point were used to characterize this ligand and its metal complexes. Elemental analysis data show that the general formula of the metal complexes formed is [M(L)2Cl2] nCl.H2O, where L = Mannich base ligand and M = Au(III) and Pt(IV), and n = 1,2 respectively with octahedral structure. The chemical structure and morphology of the metal oxide nanoparticles are investigated using FT-IR, XRD, AFM, TEM, and SEM. In the next step, the ligand and its complexes, SiO2/PtO2 and SiO2/Au2O3 nanoparticles were examined to investigate their toxicity (in vitro) as an anticancer agent to MDA-MB-231 cell lines by using different concentrations (50, 100, 200, and 400 µg /mL). Based on the results obtained from the cytotoxic activity, it can be concluded that the synthesized compounds are promising as new cancer candidates in the future, especially in high concentrations
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| format | Article |
| id | doaj-art-97be68a6b0cd495d814d485ff8b9e0ae |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-97be68a6b0cd495d814d485ff8b9e0ae2025-08-20T03:56:55ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-08-0121810.21123/bsj.2024.8834Synthesis, Structural, Morphological Characterization, and Cytotoxicity Assays of Metal Complexes Decorated SiO2 Nanoparticles Against Breast Cancer Cell Lines (MDA-MB-231)Alya'a J. Ahmed0https://orcid.org/0000-0002-1093-2907Mahasin F. Alias1https://orcid.org/0000-0002-3375-1797Ministry of Higher Education and Scientific Research,Baghdad, Iraq.Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq. This study examines the new synthesis of Pt (IV) and Au (III) Mannich base complexes derived from ciprofloxacin. The complexes were then used as precursors to prepare SiO2/PtO2 and SiO2/Au2O3 nanoparticles by depositing the synthesized complexes on porous silica nanoparticles. Elemental analysis, FT-IR, UV-vis, molar conductivity measurements, and melting point were used to characterize this ligand and its metal complexes. Elemental analysis data show that the general formula of the metal complexes formed is [M(L)2Cl2] nCl.H2O, where L = Mannich base ligand and M = Au(III) and Pt(IV), and n = 1,2 respectively with octahedral structure. The chemical structure and morphology of the metal oxide nanoparticles are investigated using FT-IR, XRD, AFM, TEM, and SEM. In the next step, the ligand and its complexes, SiO2/PtO2 and SiO2/Au2O3 nanoparticles were examined to investigate their toxicity (in vitro) as an anticancer agent to MDA-MB-231 cell lines by using different concentrations (50, 100, 200, and 400 µg /mL). Based on the results obtained from the cytotoxic activity, it can be concluded that the synthesized compounds are promising as new cancer candidates in the future, especially in high concentrations https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8834Cytotoxicity assays, Ciprofloxacin, Metal oxides Nanoparticles, Mannich base complexes, Silica nanoparticles |
| spellingShingle | Alya'a J. Ahmed Mahasin F. Alias Synthesis, Structural, Morphological Characterization, and Cytotoxicity Assays of Metal Complexes Decorated SiO2 Nanoparticles Against Breast Cancer Cell Lines (MDA-MB-231) مجلة بغداد للعلوم Cytotoxicity assays, Ciprofloxacin, Metal oxides Nanoparticles, Mannich base complexes, Silica nanoparticles |
| title | Synthesis, Structural, Morphological Characterization, and Cytotoxicity Assays of Metal Complexes Decorated SiO2 Nanoparticles Against Breast Cancer Cell Lines (MDA-MB-231) |
| title_full | Synthesis, Structural, Morphological Characterization, and Cytotoxicity Assays of Metal Complexes Decorated SiO2 Nanoparticles Against Breast Cancer Cell Lines (MDA-MB-231) |
| title_fullStr | Synthesis, Structural, Morphological Characterization, and Cytotoxicity Assays of Metal Complexes Decorated SiO2 Nanoparticles Against Breast Cancer Cell Lines (MDA-MB-231) |
| title_full_unstemmed | Synthesis, Structural, Morphological Characterization, and Cytotoxicity Assays of Metal Complexes Decorated SiO2 Nanoparticles Against Breast Cancer Cell Lines (MDA-MB-231) |
| title_short | Synthesis, Structural, Morphological Characterization, and Cytotoxicity Assays of Metal Complexes Decorated SiO2 Nanoparticles Against Breast Cancer Cell Lines (MDA-MB-231) |
| title_sort | synthesis structural morphological characterization and cytotoxicity assays of metal complexes decorated sio2 nanoparticles against breast cancer cell lines mda mb 231 |
| topic | Cytotoxicity assays, Ciprofloxacin, Metal oxides Nanoparticles, Mannich base complexes, Silica nanoparticles |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8834 |
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