KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Hypermethylation of tumor suppressor genes is a hallmark of leukemia. The hypomethylating agent decitabine covalently binds, and degrades DNA (cytosine‐5)‐methyltransferase 1 (DNMT1). Structural similarities within DNA‐binding domains of DNMT1, and the leukemic driver histone‐lysine N‐methyltransfer...

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Bibliographic Details
Main Authors: Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Molecular Oncology
Subjects:
acute leukemia
decitabine
DNMT1
KMT2A
menin
revumenib
Online Access:https://doi.org/10.1002/1878-0261.13792
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