Delayed Presentation of Morphine-Induced Respiratory Depression: A Case Report
Opioid-induced respiratory depression (OIRD) is a serious threat that can lead to brain damage and death. Morphine is a commonly used opioid for postoperative pain management. However, the window during which patients are at risk of OIRD, as described in the literature, is largely based on the drug’...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Dr. Sulaiman Al Habib Medical Journal |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/DSHMJ.DSHMJ_75_24 |
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| author | Islam Mukhtar Omar Mudawi Abdulrahman H. Alashkar Raed Ali Abuajamieh |
| author_facet | Islam Mukhtar Omar Mudawi Abdulrahman H. Alashkar Raed Ali Abuajamieh |
| author_sort | Islam Mukhtar |
| collection | DOAJ |
| description | Opioid-induced respiratory depression (OIRD) is a serious threat that can lead to brain damage and death. Morphine is a commonly used opioid for postoperative pain management. However, the window during which patients are at risk of OIRD, as described in the literature, is largely based on the drug’s pharmacokinetics rather than actual clinical experiences. For morphine, OIRD is generally noted to occur within 5–72 min following administration. In this case, we present the case of a 73-year-old female who underwent open herniorrhaphy and developed respiratory depression 5 h after receiving an intravenous (IV) dose of morphine. The diagnosis of OIRD was confirmed by a positive response to naloxone. Defining a window during which patients are at risk of developing respiratory impairment after opioid administration has significant practical implications for the management of postoperative patients. Based on its half-life and our clinical experience, healthy patients receiving a therapeutic dose of IV morphine may develop OIRD for up to 6 h following administration. During this period, close monitoring is strongly recommended to ensure early detection and intervention if respiratory depression occurs. |
| format | Article |
| id | doaj-art-97bc2d3e16a04214a29b90faaa1f6844 |
| institution | Kabale University |
| issn | 2666-819X 2590-3349 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dr. Sulaiman Al Habib Medical Journal |
| spelling | doaj-art-97bc2d3e16a04214a29b90faaa1f68442025-08-21T05:06:29ZengWolters Kluwer Medknow PublicationsDr. Sulaiman Al Habib Medical Journal2666-819X2590-33492024-10-016424925110.4103/DSHMJ.DSHMJ_75_24Delayed Presentation of Morphine-Induced Respiratory Depression: A Case ReportIslam MukhtarOmar MudawiAbdulrahman H. AlashkarRaed Ali AbuajamiehOpioid-induced respiratory depression (OIRD) is a serious threat that can lead to brain damage and death. Morphine is a commonly used opioid for postoperative pain management. However, the window during which patients are at risk of OIRD, as described in the literature, is largely based on the drug’s pharmacokinetics rather than actual clinical experiences. For morphine, OIRD is generally noted to occur within 5–72 min following administration. In this case, we present the case of a 73-year-old female who underwent open herniorrhaphy and developed respiratory depression 5 h after receiving an intravenous (IV) dose of morphine. The diagnosis of OIRD was confirmed by a positive response to naloxone. Defining a window during which patients are at risk of developing respiratory impairment after opioid administration has significant practical implications for the management of postoperative patients. Based on its half-life and our clinical experience, healthy patients receiving a therapeutic dose of IV morphine may develop OIRD for up to 6 h following administration. During this period, close monitoring is strongly recommended to ensure early detection and intervention if respiratory depression occurs.https://journals.lww.com/10.4103/DSHMJ.DSHMJ_75_24morphineopioidpostoperativerespiratory depression |
| spellingShingle | Islam Mukhtar Omar Mudawi Abdulrahman H. Alashkar Raed Ali Abuajamieh Delayed Presentation of Morphine-Induced Respiratory Depression: A Case Report Dr. Sulaiman Al Habib Medical Journal morphine opioid postoperative respiratory depression |
| title | Delayed Presentation of Morphine-Induced Respiratory Depression: A Case Report |
| title_full | Delayed Presentation of Morphine-Induced Respiratory Depression: A Case Report |
| title_fullStr | Delayed Presentation of Morphine-Induced Respiratory Depression: A Case Report |
| title_full_unstemmed | Delayed Presentation of Morphine-Induced Respiratory Depression: A Case Report |
| title_short | Delayed Presentation of Morphine-Induced Respiratory Depression: A Case Report |
| title_sort | delayed presentation of morphine induced respiratory depression a case report |
| topic | morphine opioid postoperative respiratory depression |
| url | https://journals.lww.com/10.4103/DSHMJ.DSHMJ_75_24 |
| work_keys_str_mv | AT islammukhtar delayedpresentationofmorphineinducedrespiratorydepressionacasereport AT omarmudawi delayedpresentationofmorphineinducedrespiratorydepressionacasereport AT abdulrahmanhalashkar delayedpresentationofmorphineinducedrespiratorydepressionacasereport AT raedaliabuajamieh delayedpresentationofmorphineinducedrespiratorydepressionacasereport |