The structure of human retinal vasculature and interstitium in the terminal stage of primary openangle glaucoma
Purpose: to study the structural organization of the vascular bed of human retina in the terminal stage of primary open-angle glaucoma (POAG).Material and methods. We performed a comparative immunohistochemical analysis of the content of vessels in the retina of 13 eyes of patients in the terminal s...
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Real Time Ltd
2022-06-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/970 |
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| author | N. P. Bgatova N. A. Obanina A. V. Eremina A. N. Trunov V. V. Chernykh |
| author_facet | N. P. Bgatova N. A. Obanina A. V. Eremina A. N. Trunov V. V. Chernykh |
| author_sort | N. P. Bgatova |
| collection | DOAJ |
| description | Purpose: to study the structural organization of the vascular bed of human retina in the terminal stage of primary open-angle glaucoma (POAG).Material and methods. We performed a comparative immunohistochemical analysis of the content of vessels in the retina of 13 eyes of patients in the terminal stage of POAG, enucleated for medical reasons, and 17 eyes with uveal melanoma, using the markers of blood vessels endothelium CD34. The ultrastructural organization of the interstitium and endothelial cells of retinal microvessels was studied by electron microscopy and morphometry.Results. A significant increase in the volume density of the interstitium and a decrease in the volume density of CD34+-blood vessels in the retina of patients in the terminal stage of POAG, as compared with uveal melanoma, were revealed. An increased volume density of luminal and basal caveolae and the formation of transendothelial channels in the cytoplasm of endotheliocytes of retinal blood capillaries in the terminal stage of POAG were noted.Conclusion. In the terminal stage of POAG, the interstitial spaces of the retina are increased and the volume density of blood vessels is dropping. The increased volume density of luminal and basal caveolae and the formation of transendothelial channels in the cytoplasm of blood capillary endotheliocytes indicate the growth of transcytosis and the permeability of the blood-retinal barrier. |
| format | Article |
| id | doaj-art-97badbb5cd7a4026a4fb7274b828adc6 |
| institution | Kabale University |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| publishDate | 2022-06-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj-art-97badbb5cd7a4026a4fb7274b828adc62025-08-20T03:39:28ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602022-06-01152 (Прил)12112810.21516/2072-0076-2022-15-2-supplement-121-128459The structure of human retinal vasculature and interstitium in the terminal stage of primary openangle glaucomaN. P. Bgatova0N. A. Obanina1A. V. Eremina2A. N. Trunov3V. V. Chernykh4Research Institute of Clinical and Experimental Lymphology, branch of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of SciencesResearch Institute of Clinical and Experimental Lymphology, branch of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of SciencesS. Fyodorov Eye Microsurgery Clinic, Novosibirsk BranchS. Fyodorov Eye Microsurgery Clinic, Novosibirsk BranchS. Fyodorov Eye Microsurgery Clinic, Novosibirsk BranchPurpose: to study the structural organization of the vascular bed of human retina in the terminal stage of primary open-angle glaucoma (POAG).Material and methods. We performed a comparative immunohistochemical analysis of the content of vessels in the retina of 13 eyes of patients in the terminal stage of POAG, enucleated for medical reasons, and 17 eyes with uveal melanoma, using the markers of blood vessels endothelium CD34. The ultrastructural organization of the interstitium and endothelial cells of retinal microvessels was studied by electron microscopy and morphometry.Results. A significant increase in the volume density of the interstitium and a decrease in the volume density of CD34+-blood vessels in the retina of patients in the terminal stage of POAG, as compared with uveal melanoma, were revealed. An increased volume density of luminal and basal caveolae and the formation of transendothelial channels in the cytoplasm of endotheliocytes of retinal blood capillaries in the terminal stage of POAG were noted.Conclusion. In the terminal stage of POAG, the interstitial spaces of the retina are increased and the volume density of blood vessels is dropping. The increased volume density of luminal and basal caveolae and the formation of transendothelial channels in the cytoplasm of blood capillary endotheliocytes indicate the growth of transcytosis and the permeability of the blood-retinal barrier.https://roj.igb.ru/jour/article/view/970terminal stage of primary open-angle glaucomainterstitiumblood vesselsendotheliumultrastructure |
| spellingShingle | N. P. Bgatova N. A. Obanina A. V. Eremina A. N. Trunov V. V. Chernykh The structure of human retinal vasculature and interstitium in the terminal stage of primary openangle glaucoma Российский офтальмологический журнал terminal stage of primary open-angle glaucoma interstitium blood vessels endothelium ultrastructure |
| title | The structure of human retinal vasculature and interstitium in the terminal stage of primary openangle glaucoma |
| title_full | The structure of human retinal vasculature and interstitium in the terminal stage of primary openangle glaucoma |
| title_fullStr | The structure of human retinal vasculature and interstitium in the terminal stage of primary openangle glaucoma |
| title_full_unstemmed | The structure of human retinal vasculature and interstitium in the terminal stage of primary openangle glaucoma |
| title_short | The structure of human retinal vasculature and interstitium in the terminal stage of primary openangle glaucoma |
| title_sort | structure of human retinal vasculature and interstitium in the terminal stage of primary openangle glaucoma |
| topic | terminal stage of primary open-angle glaucoma interstitium blood vessels endothelium ultrastructure |
| url | https://roj.igb.ru/jour/article/view/970 |
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