Liver Damage in Type 1 Diabetes Mellitus
Aim. An up-to-date review of the prevalence, pathogenesis, diagnosis and management of hepatological complications of type 1 diabetes mellitus (T1D).Key points. Diabetes type 1 causes a markedly more common liver injury than traditionally assumed. Three types of hepatic damage have been described to...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2021-06-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/548 |
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| _version_ | 1823860145322459136 |
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| author | A. O. Bueverov A. V. Zilov |
| author_facet | A. O. Bueverov A. V. Zilov |
| author_sort | A. O. Bueverov |
| collection | DOAJ |
| description | Aim. An up-to-date review of the prevalence, pathogenesis, diagnosis and management of hepatological complications of type 1 diabetes mellitus (T1D).Key points. Diabetes type 1 causes a markedly more common liver injury than traditionally assumed. Three types of hepatic damage have been described to date in T1D patients, steatosis, glycogen hepatopathy and diabetic hepatosclerosis, with the latter two apparently pathognomonic of this diabetes type. Their pathogenesis is complex and not fully understood. Its important link is a likely inherited non-physiological insulin supply to the tissue, especially at marked glycaemic fluctuations. An adequate glycaemic control is the main prevention and treatment measure in these conditions. The practitioner’s understanding of liver damage in T1D is an earnest to avoid unnecessary tests and ineffective medications.Conclusion. Both endocrinologists and internists ought to contemplate the possibility of liver involvement in T1D for improving the patient outcomes. |
| format | Article |
| id | doaj-art-97ae0ad15c7748dbbe3587d94b01b5f7 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2021-06-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-97ae0ad15c7748dbbe3587d94b01b5f72025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732021-06-0131271310.22416/1382-4376-2021-31-2-7-13419Liver Damage in Type 1 Diabetes MellitusA. O. Bueverov0A. V. Zilov1Sechenov First Moscow State University (Sechenov University); Vladimirsky Moscow Regional Research and Clinical InstituteSechenov First Moscow State University (Sechenov University)Aim. An up-to-date review of the prevalence, pathogenesis, diagnosis and management of hepatological complications of type 1 diabetes mellitus (T1D).Key points. Diabetes type 1 causes a markedly more common liver injury than traditionally assumed. Three types of hepatic damage have been described to date in T1D patients, steatosis, glycogen hepatopathy and diabetic hepatosclerosis, with the latter two apparently pathognomonic of this diabetes type. Their pathogenesis is complex and not fully understood. Its important link is a likely inherited non-physiological insulin supply to the tissue, especially at marked glycaemic fluctuations. An adequate glycaemic control is the main prevention and treatment measure in these conditions. The practitioner’s understanding of liver damage in T1D is an earnest to avoid unnecessary tests and ineffective medications.Conclusion. Both endocrinologists and internists ought to contemplate the possibility of liver involvement in T1D for improving the patient outcomes.https://www.gastro-j.ru/jour/article/view/548сахарный диабет 1-го типапеченьстеатозгликогеновая гепатопатиядиабетический гепатосклероз |
| spellingShingle | A. O. Bueverov A. V. Zilov Liver Damage in Type 1 Diabetes Mellitus Российский журнал гастроэнтерологии, гепатологии, колопроктологии сахарный диабет 1-го типа печень стеатоз гликогеновая гепатопатия диабетический гепатосклероз |
| title | Liver Damage in Type 1 Diabetes Mellitus |
| title_full | Liver Damage in Type 1 Diabetes Mellitus |
| title_fullStr | Liver Damage in Type 1 Diabetes Mellitus |
| title_full_unstemmed | Liver Damage in Type 1 Diabetes Mellitus |
| title_short | Liver Damage in Type 1 Diabetes Mellitus |
| title_sort | liver damage in type 1 diabetes mellitus |
| topic | сахарный диабет 1-го типа печень стеатоз гликогеновая гепатопатия диабетический гепатосклероз |
| url | https://www.gastro-j.ru/jour/article/view/548 |
| work_keys_str_mv | AT aobueverov liverdamageintype1diabetesmellitus AT avzilov liverdamageintype1diabetesmellitus |