Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways

Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways

Abstract Diabetic wound therapy faces significant challenges due to the complexity of the wound microenvironment, especially dysregulated immune cell responses and persistent pro-inflammatory sate. Targeting immune cells to reverse pathological wound conditions has increasingly become a promising st...

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Bibliographic Details
Main Authors: Yunlong Fan, Jiaman Yang, Yulin Xie, Xin Yang, He Zhu, Yuanyuan Liu, Zhikuan Xia, Shuaifei Ji, Rongya Yang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Nanobiotechnology
Subjects:
Inflammatory memory
Mimetic nanovesicles
Epidermal stem cells
Neutrophils
Diabetic wounds
Online Access:https://doi.org/10.1186/s12951-025-03193-5
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