Impact of hematologic inflammatory markers on the prognosis of geriatric hip fracture: a systematic review and meta-analysis
Abstract Background Geriatric hip fractures pose a significant health burden, and inflammation may play a role in the short- and long-term prognosis. However, the prognostic significance of hematologic inflammatory markers in geriatric patients with fractures is not understood. The aim of this syste...
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2024-12-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-024-02211-w |
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| author | Wei-Gang Pan Yu-Ching Chou Jia-Lin Wu Tsu-Te Yeh |
| author_facet | Wei-Gang Pan Yu-Ching Chou Jia-Lin Wu Tsu-Te Yeh |
| author_sort | Wei-Gang Pan |
| collection | DOAJ |
| description | Abstract Background Geriatric hip fractures pose a significant health burden, and inflammation may play a role in the short- and long-term prognosis. However, the prognostic significance of hematologic inflammatory markers in geriatric patients with fractures is not understood. The aim of this systematic review and meta-analysis was to assess the prognostic implications of systemic inflammatory markers on the long-term mortality of older patients with hip fractures. Methods PubMed, EMBASE, and Cochrane CENTRAL were searched from inception to December 19, 2023. Prospective, retrospective cohort, and case–control studies investigating the prognostic impact of hematologic inflammatory markers on mortality after hip fracture were eligible. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were calculated to determine the associations between the markers and mortality risk, with heterogeneity assessed by I2 statistic. The quality of the studies was appraised using the Newcastle–Ottawa Scale. Results Ultimately, 7 retrospective studies involving a total of 7212 patients were included. The meta-analysis revealed that the neutrophil-to-lymphocyte ratio (NLR) (HR = 1.04, 95% CI 1.02–1.08), systemic immune–inflammatory index (SII) (HR = 1.03, 95% CI 1.01–1.05), and red cell distribution width (RDW) (HR = 1.07, 95% CI 1.01–1.14) independently correlated with increased long-term mortality. Conclusions Elevated NLR, SII, and RDW are independently associated with increased long-term mortality in older patients with hip fractures. These findings imply the potential value of incorporating these inflammatory indicators to aid in prognostic stratification of geriatric patients with hip fractures. |
| format | Article |
| id | doaj-art-97a8470022164188a8a1c98ff90f02fe |
| institution | OA Journals |
| issn | 2047-783X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-97a8470022164188a8a1c98ff90f02fe2025-08-20T02:31:48ZengBMCEuropean Journal of Medical Research2047-783X2024-12-012911910.1186/s40001-024-02211-wImpact of hematologic inflammatory markers on the prognosis of geriatric hip fracture: a systematic review and meta-analysisWei-Gang Pan0Yu-Ching Chou1Jia-Lin Wu2Tsu-Te Yeh3Department of Orthopaedic Surgery, Tri-Service General HospitalSchool of Public Health, National Defense Medical CenterDepartment of Orthopedics, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Orthopaedic Surgery, Tri-Service General HospitalAbstract Background Geriatric hip fractures pose a significant health burden, and inflammation may play a role in the short- and long-term prognosis. However, the prognostic significance of hematologic inflammatory markers in geriatric patients with fractures is not understood. The aim of this systematic review and meta-analysis was to assess the prognostic implications of systemic inflammatory markers on the long-term mortality of older patients with hip fractures. Methods PubMed, EMBASE, and Cochrane CENTRAL were searched from inception to December 19, 2023. Prospective, retrospective cohort, and case–control studies investigating the prognostic impact of hematologic inflammatory markers on mortality after hip fracture were eligible. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were calculated to determine the associations between the markers and mortality risk, with heterogeneity assessed by I2 statistic. The quality of the studies was appraised using the Newcastle–Ottawa Scale. Results Ultimately, 7 retrospective studies involving a total of 7212 patients were included. The meta-analysis revealed that the neutrophil-to-lymphocyte ratio (NLR) (HR = 1.04, 95% CI 1.02–1.08), systemic immune–inflammatory index (SII) (HR = 1.03, 95% CI 1.01–1.05), and red cell distribution width (RDW) (HR = 1.07, 95% CI 1.01–1.14) independently correlated with increased long-term mortality. Conclusions Elevated NLR, SII, and RDW are independently associated with increased long-term mortality in older patients with hip fractures. These findings imply the potential value of incorporating these inflammatory indicators to aid in prognostic stratification of geriatric patients with hip fractures.https://doi.org/10.1186/s40001-024-02211-wHip fractureGeriatricPrognosisHematologic inflammatory markerSystemic immune–inflammatory index (SII)Neutrophil-to-lymphocyte ratio (NLR) |
| spellingShingle | Wei-Gang Pan Yu-Ching Chou Jia-Lin Wu Tsu-Te Yeh Impact of hematologic inflammatory markers on the prognosis of geriatric hip fracture: a systematic review and meta-analysis European Journal of Medical Research Hip fracture Geriatric Prognosis Hematologic inflammatory marker Systemic immune–inflammatory index (SII) Neutrophil-to-lymphocyte ratio (NLR) |
| title | Impact of hematologic inflammatory markers on the prognosis of geriatric hip fracture: a systematic review and meta-analysis |
| title_full | Impact of hematologic inflammatory markers on the prognosis of geriatric hip fracture: a systematic review and meta-analysis |
| title_fullStr | Impact of hematologic inflammatory markers on the prognosis of geriatric hip fracture: a systematic review and meta-analysis |
| title_full_unstemmed | Impact of hematologic inflammatory markers on the prognosis of geriatric hip fracture: a systematic review and meta-analysis |
| title_short | Impact of hematologic inflammatory markers on the prognosis of geriatric hip fracture: a systematic review and meta-analysis |
| title_sort | impact of hematologic inflammatory markers on the prognosis of geriatric hip fracture a systematic review and meta analysis |
| topic | Hip fracture Geriatric Prognosis Hematologic inflammatory marker Systemic immune–inflammatory index (SII) Neutrophil-to-lymphocyte ratio (NLR) |
| url | https://doi.org/10.1186/s40001-024-02211-w |
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