Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma
Purpose: to study the dynamics of blood plasma electrochemical parameters in patients with severe combined trauma before and after fresh frozen plasma (FFP) transfusions.Materials and methods. The open circuit potential (OCP) of platinum electrode and antioxidant activity of blood plasma were studie...
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2020-08-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1938 |
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| author | I. V. Goroncharovskaya A. K. Evseev A. K. Shabanov V. V. Kulabukhov A. N. Kuzovlev K. A. Popugaev S. S. Petrikov |
| author_facet | I. V. Goroncharovskaya A. K. Evseev A. K. Shabanov V. V. Kulabukhov A. N. Kuzovlev K. A. Popugaev S. S. Petrikov |
| author_sort | I. V. Goroncharovskaya |
| collection | DOAJ |
| description | Purpose: to study the dynamics of blood plasma electrochemical parameters in patients with severe combined trauma before and after fresh frozen plasma (FFP) transfusions.Materials and methods. The open circuit potential (OCP) of platinum electrode and antioxidant activity of blood plasma were studied in 35 patients with severe combined trauma and 35 post-FFP samples with at least 6-month shelf life. The electrochemical parameters of patients’ blood plasma were analyzed before transfusion, and 1 hr. and 24 hrs. after transfusion.Results. OCP measured in FFP was found to be more positive vs. OCP measured in recipients' blood plasma in 34 out of 35 cases (97%). It has been shown that in patients with severe combined trauma, OCP increased from 5.047 [-7.553; 12.976] mV to 12.827 [-1.372; 24.764] mV and antioxidant activity decreased 24 hours after FFP transfusion from 16.979 [11.302; 20.946] µC to 13.551 [9.288; 18.405] µC. After FFP transfusion, there were no significant changes in clinical blood parameters.Conclusion. By measuring electrochemical parameters of blood plasma in patients with severe combined trauma before and after FFP transfusions, it was discovered that in spite of absence of changes in blood parameters by routine methods, there are changes in the condition of the antioxidant system of the body, which manifest in the bias of patients’ blood plasma OCP towards higher positive values and decreased antioxidant activity. Redox imbalance in the body might cause the oxidative stress development. |
| format | Article |
| id | doaj-art-979f2921ae30474081f0c104585fcc2c |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-979f2921ae30474081f0c104585fcc2c2025-08-20T03:59:40ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102020-08-0116441310.15360/1813-9779-2020-4-4-131749Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined TraumaI. V. Goroncharovskaya0A. K. Evseev1A. K. Shabanov2V. V. Kulabukhov3A. N. Kuzovlev4K. A. Popugaev5S. S. Petrikov6N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentN. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentN. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department; V. A. Negovsky Research Institute of General Reanimatology,Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyN. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentV. A. Negovsky Research Institute of General Reanimatology,Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyN. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentN. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentPurpose: to study the dynamics of blood plasma electrochemical parameters in patients with severe combined trauma before and after fresh frozen plasma (FFP) transfusions.Materials and methods. The open circuit potential (OCP) of platinum electrode and antioxidant activity of blood plasma were studied in 35 patients with severe combined trauma and 35 post-FFP samples with at least 6-month shelf life. The electrochemical parameters of patients’ blood plasma were analyzed before transfusion, and 1 hr. and 24 hrs. after transfusion.Results. OCP measured in FFP was found to be more positive vs. OCP measured in recipients' blood plasma in 34 out of 35 cases (97%). It has been shown that in patients with severe combined trauma, OCP increased from 5.047 [-7.553; 12.976] mV to 12.827 [-1.372; 24.764] mV and antioxidant activity decreased 24 hours after FFP transfusion from 16.979 [11.302; 20.946] µC to 13.551 [9.288; 18.405] µC. After FFP transfusion, there were no significant changes in clinical blood parameters.Conclusion. By measuring electrochemical parameters of blood plasma in patients with severe combined trauma before and after FFP transfusions, it was discovered that in spite of absence of changes in blood parameters by routine methods, there are changes in the condition of the antioxidant system of the body, which manifest in the bias of patients’ blood plasma OCP towards higher positive values and decreased antioxidant activity. Redox imbalance in the body might cause the oxidative stress development.https://www.reanimatology.com/rmt/article/view/1938open circuit potentialplatinum electrodetransfusionantioxidant activitysevere combined traumablood plasma |
| spellingShingle | I. V. Goroncharovskaya A. K. Evseev A. K. Shabanov V. V. Kulabukhov A. N. Kuzovlev K. A. Popugaev S. S. Petrikov Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma Общая реаниматология open circuit potential platinum electrode transfusion antioxidant activity severe combined trauma blood plasma |
| title | Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma |
| title_full | Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma |
| title_fullStr | Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma |
| title_full_unstemmed | Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma |
| title_short | Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma |
| title_sort | effect of fresh frozen plasma transfusion on electrochemical parameters of blood plasma in patients with severe combined trauma |
| topic | open circuit potential platinum electrode transfusion antioxidant activity severe combined trauma blood plasma |
| url | https://www.reanimatology.com/rmt/article/view/1938 |
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