Berberine protects against lung injury induced by liver transplantation through upregulating PPARγ and suppressing NF-κB-mediated pyroptosis pathway

Berberine protects against lung injury induced by liver transplantation through upregulating PPARγ and suppressing NF-κB-mediated pyroptosis pathway

ABSTRACT Purpose: We builted a orthotopic autologous liver transplantation (OALT) model in rats to evaluate the possible mechanisms of berberine against lung injury. Methods: Forty clean grade Sprague-Dawley rats (male, healthy, 250–280 g) were divided into five groups (n = 8): sham-operated group...

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Bibliographic Details
Main Authors: Wenna Liu, Xiaohui Liang, Mingxia Huo, Yongwang Wang, Guanghua Zhang
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2025-07-01
Series:Acta Cirúrgica Brasileira
Subjects:
Liver Transplantation
Lung Injury
Pyroptosis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100233&lng=en&tlng=en
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