Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis

Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis

Abstract Background Ulcerative colitis (UC) is a persistent inflammatory bowels disease (IBD) characterized by immune response dysregulation and metabolic disruptions. Tryptophan metabolism has been believed as a significant factor in UC pathogenesis, with specific metabolites influencing immune mod...

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Bibliographic Details
Main Authors: Guorong Chen, Hongying Qi, Li Jiang, Shijie Sun, Junhai Zhang, Jiali Yu, Fang Liu, Yanli Zhang, Shiyu Du
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Tryptophan metabolism
Ulcerative colitis
Macrophage
Online Access:https://doi.org/10.1186/s12967-024-05934-w
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https://doi.org/10.1186/s12967-024-05934-w

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