Total flavonoids of Dracocephalum moldavica L. alleviate cognitive impairment via TNF-α/NF-κB p65 signaling pathway in vascular dementia rats

ObjectiveThis study aims to elucidate the neuroprotective effects and underlying mechanisms of total flavonoids of Dracocephalum moldavica L. (TFDM) in VaD by using network pharmacology and in vivo validation.MethodsThe network pharmacology was used to explore the mechanism of TFDM to improve VaD. A...

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Bibliographic Details
Main Authors:	Shangjia Ma, Jianxin Jia, Lie Wu, Kai Tian, Lu Wang, Hua Li, Jiayu Lv, Dewang Gao, Zhanjun Yang, Xia Guo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Pharmacology
Subjects:	total flavonoids of Dracocephalum moldavica L. vascular dementia network pharmacology neuroinflammation TNF-α/NF-κB p65 signaling pathway blood-brain barrier
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1640272/full
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Total flavonoids of Dracocephalum moldavica L. alleviate cognitive impairment via TNF-α/NF-κB p65 signaling pathway in vascular dementia rats

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