Single-Cell RNA Sequencing Integrated with Bulk-RNA Sequencing Analysis Reveals Prognostic Signatures Based on PANoptosis in Hepatocellular Carcinoma
Jiyin Wang,1– 5,* Xue Yin,1– 4,6,* Ziyi Li,1– 4,* Pu Liang,1– 4,* Yipeng Wang,1– 4 Xingling Li,1– 4 Wenying Qiao,1– 4 Chaoyang Xiong,1– 4 Minghang Yu,1– 4 Xiaoyan Ding,1– 4 Xi Wang1– 4,7 1National Key Laboratory of Intelligent Tracking and Forecasting...
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Dove Medical Press
2025-07-01
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| Series: | Journal of Hepatocellular Carcinoma |
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| Online Access: | https://www.dovepress.com/single-cell-rna-sequencing-integrated-with-bulk-rna-sequencing-analysi-peer-reviewed-fulltext-article-JHC |
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| author | Wang J Yin X Li Z Liang P Wang Y Li X Qiao W Xiong C Yu M Ding X Wang X |
| author_facet | Wang J Yin X Li Z Liang P Wang Y Li X Qiao W Xiong C Yu M Ding X Wang X |
| author_sort | Wang J |
| collection | DOAJ |
| description | Jiyin Wang,1– 5,* Xue Yin,1– 4,6,* Ziyi Li,1– 4,* Pu Liang,1– 4,* Yipeng Wang,1– 4 Xingling Li,1– 4 Wenying Qiao,1– 4 Chaoyang Xiong,1– 4 Minghang Yu,1– 4 Xiaoyan Ding,1– 4 Xi Wang1– 4,7 1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Viral Infectious Disease, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Beijing Institute of Infectious Diseases, Beijing, People’s Republic of China; 4National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 5HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, People’s Republic of China; 6Department of Infectious Disease, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People’s Republic of China; 7Department of Oncology, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoyan Ding, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China, Tel/Fax +86-13811560276 ; +86-17316198975, Email dingxiaoyan198111@163.com Xi Wang, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China, Tel/Fax +86-13811560276 ; +86-17316198975, Email xiwang@ccmu.edu.cnPurpose: Drug resistance severely compromises therapeutic efficacy in hepatocellular carcinoma (HCC); however, the selection of precise treatment strategies for patients remains a critical unmet clinical need. This study investigated PANoptosis-related mechanisms underlying HCC progression to identify actionable therapeutic targets and optimize patient-specific treatment outcomes.Patients and Methods: Multi-omics analysis (single-cell/bulk RNA sequencing) combined with machine learning was used to identify the PANoptosis-related prognostic features. The association of PANoptosis-related expression with the tumor immune microenvironment and drugs was explored using bioinformatic analysis and experimental studies.Results: High PANoptosis risk exhibited immunosuppressive microenvironments and therapeutic resistance. The PANoptosis-related gene YIF1B has emerged as a dual prognostic biomarker and tumor driver that promotes proliferation, and is linked to immune dysfunction and drug resistance.Conclusion: YIF1B may be a promising therapeutic target. This PANoptosis framework bridges molecular mechanisms to clinical management, offering strategies for personalized HCC therapy and overcoming treatment resistance. Keywords: PANoptosis, hepatocellular carcinoma, YIF1B, drug resistant |
| format | Article |
| id | doaj-art-976f291ce50a4751a3a8cf110be79028 |
| institution | Kabale University |
| issn | 2253-5969 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Hepatocellular Carcinoma |
| spelling | doaj-art-976f291ce50a4751a3a8cf110be790282025-08-20T03:56:08ZengDove Medical PressJournal of Hepatocellular Carcinoma2253-59692025-07-01Volume 12Issue 116611676105230Single-Cell RNA Sequencing Integrated with Bulk-RNA Sequencing Analysis Reveals Prognostic Signatures Based on PANoptosis in Hepatocellular CarcinomaWang JYin X0Li ZLiang PWang YLi XQiao W1Xiong CYu MDing XWang X2Cancer center, Beijing Ditan Hospital, Capital Medical UniversityNational Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University,Institute of Infectious DiseasesJiyin Wang,1– 5,* Xue Yin,1– 4,6,* Ziyi Li,1– 4,* Pu Liang,1– 4,* Yipeng Wang,1– 4 Xingling Li,1– 4 Wenying Qiao,1– 4 Chaoyang Xiong,1– 4 Minghang Yu,1– 4 Xiaoyan Ding,1– 4 Xi Wang1– 4,7 1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Viral Infectious Disease, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Beijing Institute of Infectious Diseases, Beijing, People’s Republic of China; 4National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 5HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, People’s Republic of China; 6Department of Infectious Disease, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People’s Republic of China; 7Department of Oncology, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoyan Ding, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China, Tel/Fax +86-13811560276 ; +86-17316198975, Email dingxiaoyan198111@163.com Xi Wang, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China, Tel/Fax +86-13811560276 ; +86-17316198975, Email xiwang@ccmu.edu.cnPurpose: Drug resistance severely compromises therapeutic efficacy in hepatocellular carcinoma (HCC); however, the selection of precise treatment strategies for patients remains a critical unmet clinical need. This study investigated PANoptosis-related mechanisms underlying HCC progression to identify actionable therapeutic targets and optimize patient-specific treatment outcomes.Patients and Methods: Multi-omics analysis (single-cell/bulk RNA sequencing) combined with machine learning was used to identify the PANoptosis-related prognostic features. The association of PANoptosis-related expression with the tumor immune microenvironment and drugs was explored using bioinformatic analysis and experimental studies.Results: High PANoptosis risk exhibited immunosuppressive microenvironments and therapeutic resistance. The PANoptosis-related gene YIF1B has emerged as a dual prognostic biomarker and tumor driver that promotes proliferation, and is linked to immune dysfunction and drug resistance.Conclusion: YIF1B may be a promising therapeutic target. This PANoptosis framework bridges molecular mechanisms to clinical management, offering strategies for personalized HCC therapy and overcoming treatment resistance. Keywords: PANoptosis, hepatocellular carcinoma, YIF1B, drug resistanthttps://www.dovepress.com/single-cell-rna-sequencing-integrated-with-bulk-rna-sequencing-analysi-peer-reviewed-fulltext-article-JHCPANoptosisHepatocellular carcinomaYIF1BDrug resistant. |
| spellingShingle | Wang J Yin X Li Z Liang P Wang Y Li X Qiao W Xiong C Yu M Ding X Wang X Single-Cell RNA Sequencing Integrated with Bulk-RNA Sequencing Analysis Reveals Prognostic Signatures Based on PANoptosis in Hepatocellular Carcinoma Journal of Hepatocellular Carcinoma PANoptosis Hepatocellular carcinoma YIF1B Drug resistant. |
| title | Single-Cell RNA Sequencing Integrated with Bulk-RNA Sequencing Analysis Reveals Prognostic Signatures Based on PANoptosis in Hepatocellular Carcinoma |
| title_full | Single-Cell RNA Sequencing Integrated with Bulk-RNA Sequencing Analysis Reveals Prognostic Signatures Based on PANoptosis in Hepatocellular Carcinoma |
| title_fullStr | Single-Cell RNA Sequencing Integrated with Bulk-RNA Sequencing Analysis Reveals Prognostic Signatures Based on PANoptosis in Hepatocellular Carcinoma |
| title_full_unstemmed | Single-Cell RNA Sequencing Integrated with Bulk-RNA Sequencing Analysis Reveals Prognostic Signatures Based on PANoptosis in Hepatocellular Carcinoma |
| title_short | Single-Cell RNA Sequencing Integrated with Bulk-RNA Sequencing Analysis Reveals Prognostic Signatures Based on PANoptosis in Hepatocellular Carcinoma |
| title_sort | single cell rna sequencing integrated with bulk rna sequencing analysis reveals prognostic signatures based on panoptosis in hepatocellular carcinoma |
| topic | PANoptosis Hepatocellular carcinoma YIF1B Drug resistant. |
| url | https://www.dovepress.com/single-cell-rna-sequencing-integrated-with-bulk-rna-sequencing-analysi-peer-reviewed-fulltext-article-JHC |
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