Clinical and Laboratory Analysis of Children Who Follow Up with Thrombocytopenia: A Retrospective Study
Introduction: Platelets are cells that play an important role in the first phase of hemostasis, where the clot plug is formed. Disorders in the number or function of platelets can lead to bleeding. While many conditions are responsible for the etiology of thrombocytopenia in childhood, the most comm...
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Galenos Publishing House
2025-04-01
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| Series: | Güncel Pediatri |
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| Online Access: | https://www.guncelpediatri.com/articles/trombositopeni-on-tanisi-ile-tetkik-edilen-cocuklarin-klinik-ve-laboratuvar-bulgularinin-retrospektif-incelenmesi/doi/jcp.2024.93695 |
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| author | Yasemin Denkboy Öngen Birol Baytan |
| author_facet | Yasemin Denkboy Öngen Birol Baytan |
| author_sort | Yasemin Denkboy Öngen |
| collection | DOAJ |
| description | Introduction: Platelets are cells that play an important role in the first phase of hemostasis, where the clot plug is formed. Disorders in the number or function of platelets can lead to bleeding. While many conditions are responsible for the etiology of thrombocytopenia in childhood, the most common cause is immune thrombocytopenia. The aim of the study was to investigate the causes, evaluate treatment and follow-up strategies, and reduce delays in diagnosis and treatment in children who develop thrombocytopenia.
Materials and Methods: In our study, 1500 patients who applied to our clinic between January 2010 and December 2015 and were given at least one of the ICD codes D69.3, D69.4, D69.5, and D69.6 were evaluated. When patients who did not meet the inclusion criteria were excluded from the study, a total of 440 patients were asked to fill out the thrombocytopenia form.
Results: In our study, the incidence of thrombocytopenia was 8.4: 100.000, and the incidence of ITP was 5.1. 59% of patients were male, and 41% were female. The mean age was 6.6±2.1 years. The most common cause of thrombocytopenia was found to be immune thrombocytopenia (ITP). 49.2% of ITP patients had a history of upper respiratory tract infection. 40 patients had a history of vaccination within the last 6 weeks. Drug-induced thrombocytopenia was detected in 10.5% of İTP patients. It was seen that 6.1% of all patients were in the neonatal period. Treatment was given to 53.1% of ITP patients. The response time to intravenous immunoglobulin and steroid treatments was 36.8±1.2 and 63.2±1.2 hours, respectively. Platelet recovery time was between 0-3 months in 80.6% of ITP patients. Of the 36 chronic İTP patients, 25 had primary ITP, and 11 had secondary ITP.
Conclusion: Thrombocytopenia is a rare laboratory result in childhood. In patients with thrombocytopenia, detailed history, physical examination, and correct laboratory tests can be used to detect congenital thrombocytopenia syndromes, leukemia, İTP, aplastic anemia or underlying infections, and solid malignancies. Considering that platelet levels return to normal spontaneously in the first three months without developing complications in most patients, it is important to apply the “watch and wait” strategy in appropriate patients. |
| format | Article |
| id | doaj-art-976af0e36306417982c30d1e0fd92f3e |
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| issn | 1304-9054 1308-6308 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Galenos Publishing House |
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| series | Güncel Pediatri |
| spelling | doaj-art-976af0e36306417982c30d1e0fd92f3e2025-08-20T02:16:55ZengGalenos Publishing HouseGüncel Pediatri1304-90541308-63082025-04-012311710.4274/jcp.2024.93695Clinical and Laboratory Analysis of Children Who Follow Up with Thrombocytopenia: A Retrospective StudyYasemin Denkboy Öngen0https://orcid.org/0000-0002-5657-4260Birol Baytan1https://orcid.org/0000-0002-9375-2855Bursa Uludağ Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Bursa, TürkiyeBursa Uludağ Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Bursa, TürkiyeIntroduction: Platelets are cells that play an important role in the first phase of hemostasis, where the clot plug is formed. Disorders in the number or function of platelets can lead to bleeding. While many conditions are responsible for the etiology of thrombocytopenia in childhood, the most common cause is immune thrombocytopenia. The aim of the study was to investigate the causes, evaluate treatment and follow-up strategies, and reduce delays in diagnosis and treatment in children who develop thrombocytopenia. Materials and Methods: In our study, 1500 patients who applied to our clinic between January 2010 and December 2015 and were given at least one of the ICD codes D69.3, D69.4, D69.5, and D69.6 were evaluated. When patients who did not meet the inclusion criteria were excluded from the study, a total of 440 patients were asked to fill out the thrombocytopenia form. Results: In our study, the incidence of thrombocytopenia was 8.4: 100.000, and the incidence of ITP was 5.1. 59% of patients were male, and 41% were female. The mean age was 6.6±2.1 years. The most common cause of thrombocytopenia was found to be immune thrombocytopenia (ITP). 49.2% of ITP patients had a history of upper respiratory tract infection. 40 patients had a history of vaccination within the last 6 weeks. Drug-induced thrombocytopenia was detected in 10.5% of İTP patients. It was seen that 6.1% of all patients were in the neonatal period. Treatment was given to 53.1% of ITP patients. The response time to intravenous immunoglobulin and steroid treatments was 36.8±1.2 and 63.2±1.2 hours, respectively. Platelet recovery time was between 0-3 months in 80.6% of ITP patients. Of the 36 chronic İTP patients, 25 had primary ITP, and 11 had secondary ITP. Conclusion: Thrombocytopenia is a rare laboratory result in childhood. In patients with thrombocytopenia, detailed history, physical examination, and correct laboratory tests can be used to detect congenital thrombocytopenia syndromes, leukemia, İTP, aplastic anemia or underlying infections, and solid malignancies. Considering that platelet levels return to normal spontaneously in the first three months without developing complications in most patients, it is important to apply the “watch and wait” strategy in appropriate patients.https://www.guncelpediatri.com/articles/trombositopeni-on-tanisi-ile-tetkik-edilen-cocuklarin-klinik-ve-laboratuvar-bulgularinin-retrospektif-incelenmesi/doi/jcp.2024.93695childhood thrombocytopeniaimmune thrombocytopenianewborn thrombocytopenia |
| spellingShingle | Yasemin Denkboy Öngen Birol Baytan Clinical and Laboratory Analysis of Children Who Follow Up with Thrombocytopenia: A Retrospective Study Güncel Pediatri childhood thrombocytopenia immune thrombocytopenia newborn thrombocytopenia |
| title | Clinical and Laboratory Analysis of Children Who Follow Up with Thrombocytopenia: A Retrospective Study |
| title_full | Clinical and Laboratory Analysis of Children Who Follow Up with Thrombocytopenia: A Retrospective Study |
| title_fullStr | Clinical and Laboratory Analysis of Children Who Follow Up with Thrombocytopenia: A Retrospective Study |
| title_full_unstemmed | Clinical and Laboratory Analysis of Children Who Follow Up with Thrombocytopenia: A Retrospective Study |
| title_short | Clinical and Laboratory Analysis of Children Who Follow Up with Thrombocytopenia: A Retrospective Study |
| title_sort | clinical and laboratory analysis of children who follow up with thrombocytopenia a retrospective study |
| topic | childhood thrombocytopenia immune thrombocytopenia newborn thrombocytopenia |
| url | https://www.guncelpediatri.com/articles/trombositopeni-on-tanisi-ile-tetkik-edilen-cocuklarin-klinik-ve-laboratuvar-bulgularinin-retrospektif-incelenmesi/doi/jcp.2024.93695 |
| work_keys_str_mv | AT yasemindenkboyongen clinicalandlaboratoryanalysisofchildrenwhofollowupwiththrombocytopeniaaretrospectivestudy AT birolbaytan clinicalandlaboratoryanalysisofchildrenwhofollowupwiththrombocytopeniaaretrospectivestudy |