Effect of water extract of bay laurel (Laurus nobilis L.) on non-alcoholic fatty liver disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) involves lipid accumulation in liver without consumption of alcohol and affects many people worldwide. NAFLD is associated with metabolic syndrome disease such as obesity, insulin resistance, hyperlipidemia, and diabetes. However, there are no pharmacologic...
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Swedish Nutrition Foundation
2025-04-01
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| Series: | Food & Nutrition Research |
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| Online Access: | https://foodandnutritionresearch.net/index.php/fnr/article/view/10668/19392 |
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| author | Minhee Lee Jeongjin Park Dakyung Kim Seong-Hoo Park Jaeeun Jung Woojin Jun Jinhak Kim Kwang-Soo Baek Ok-Kyung Kim Jeongmin Lee |
| author_facet | Minhee Lee Jeongjin Park Dakyung Kim Seong-Hoo Park Jaeeun Jung Woojin Jun Jinhak Kim Kwang-Soo Baek Ok-Kyung Kim Jeongmin Lee |
| author_sort | Minhee Lee |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) involves lipid accumulation in liver without consumption of alcohol and affects many people worldwide. NAFLD is associated with metabolic syndrome disease such as obesity, insulin resistance, hyperlipidemia, and diabetes. However, there are no pharmacologic therapies for NAFLD. Recently, there are increasing reports that several natural plants can inhibit lipid accumulation in hepatocytes. Bay laurel (Laurus nobilis L.) leaves have been used in traditional medicine for rheumatism, stomach ache, emetic, skin rashes, and earaches. Our objective was to investigate the effect of bay laurel leaves water extract (BLW) on free fatty acid (FFA) treated hepatocyte and high fructose, high fat (HFHF) diet in a mouse model of NAFLD. In vitro, lipid accumulation increased only in the FFA treated group, while BLW reduced lipid accumulation to a level comparable to that only in the FFA treated group. Cellular antioxidants were increased in the BLW compared to the only FFA-treated group, but cellular MDA levels were decreased in the BLW compared to the only FFA treated group. Cellular lipid accumulation, inflammation, and apoptosis were reduced in the BLW compared to the only FFA treated group. In vivo, serum ALT, AST, and GGT levels in the BLW supplementation group were significantly decreased compared with the HFHF group. Hepatic TC, TG, and MDA levels were significantly decreased in the HFHF+100 and HFHF+200 groups compared to the HFHF group. The hepatic antioxidant activities in the BLW supplementation groups were significantly increased compared to the HFHF group. The expression of proteins related to hepatic inflammation and apoptosis was reduced in the BLW supplementation groups compared to the HFHF group. These results suggest that BLW could be potentially useful in the treatment of NAFLD due to its inhibitory effects on hepatic lipogenesis, hepatic inflammation, and hepatic apoptosis. |
| format | Article |
| id | doaj-art-9765edf9f5e249b8aacd2f5bae302a84 |
| institution | OA Journals |
| issn | 1654-661X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Swedish Nutrition Foundation |
| record_format | Article |
| series | Food & Nutrition Research |
| spelling | doaj-art-9765edf9f5e249b8aacd2f5bae302a842025-08-20T02:13:28ZengSwedish Nutrition FoundationFood & Nutrition Research1654-661X2025-04-016911410.29219/fnr.v69.1066810668Effect of water extract of bay laurel (Laurus nobilis L.) on non-alcoholic fatty liver disease (NAFLD)Minhee Lee0Jeongjin Park1Dakyung Kim2Seong-Hoo Park3Jaeeun Jung4Woojin Jun5Jinhak Kim6Kwang-Soo Baek7Ok-Kyung Kim8Jeongmin Lee9Department of Food Innovation and Health, Kyung Hee University, Yongin 17104, KoreaDivision of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, Republic of KoreaDepartment of Medical Nutrition, Kyung Hee University, Yongin 17104, KoreaDepartment of Medical Nutrition, Kyung Hee University, Yongin 17104, KoreaDepartment of Medical Nutrition, Kyung Hee University, Yongin 17104, KoreaDivision of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, Republic of KoreaR&D Division, Daehan Chemtech Co. Ltd., Gwacheon 13840, KoreaR&D Division, Daehan Chemtech Co. Ltd., Gwacheon 13840, KoreaDivision of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, Republic of KoreaDepartment of Food Innovation and Health, Kyung Hee University, Yongin 17104, KoreaNon-alcoholic fatty liver disease (NAFLD) involves lipid accumulation in liver without consumption of alcohol and affects many people worldwide. NAFLD is associated with metabolic syndrome disease such as obesity, insulin resistance, hyperlipidemia, and diabetes. However, there are no pharmacologic therapies for NAFLD. Recently, there are increasing reports that several natural plants can inhibit lipid accumulation in hepatocytes. Bay laurel (Laurus nobilis L.) leaves have been used in traditional medicine for rheumatism, stomach ache, emetic, skin rashes, and earaches. Our objective was to investigate the effect of bay laurel leaves water extract (BLW) on free fatty acid (FFA) treated hepatocyte and high fructose, high fat (HFHF) diet in a mouse model of NAFLD. In vitro, lipid accumulation increased only in the FFA treated group, while BLW reduced lipid accumulation to a level comparable to that only in the FFA treated group. Cellular antioxidants were increased in the BLW compared to the only FFA-treated group, but cellular MDA levels were decreased in the BLW compared to the only FFA treated group. Cellular lipid accumulation, inflammation, and apoptosis were reduced in the BLW compared to the only FFA treated group. In vivo, serum ALT, AST, and GGT levels in the BLW supplementation group were significantly decreased compared with the HFHF group. Hepatic TC, TG, and MDA levels were significantly decreased in the HFHF+100 and HFHF+200 groups compared to the HFHF group. The hepatic antioxidant activities in the BLW supplementation groups were significantly increased compared to the HFHF group. The expression of proteins related to hepatic inflammation and apoptosis was reduced in the BLW supplementation groups compared to the HFHF group. These results suggest that BLW could be potentially useful in the treatment of NAFLD due to its inhibitory effects on hepatic lipogenesis, hepatic inflammation, and hepatic apoptosis.https://foodandnutritionresearch.net/index.php/fnr/article/view/10668/19392nafldbay laurel leaveslipid accumulationinflammationapoptosis |
| spellingShingle | Minhee Lee Jeongjin Park Dakyung Kim Seong-Hoo Park Jaeeun Jung Woojin Jun Jinhak Kim Kwang-Soo Baek Ok-Kyung Kim Jeongmin Lee Effect of water extract of bay laurel (Laurus nobilis L.) on non-alcoholic fatty liver disease (NAFLD) Food & Nutrition Research nafld bay laurel leaves lipid accumulation inflammation apoptosis |
| title | Effect of water extract of bay laurel (Laurus nobilis L.) on non-alcoholic fatty liver disease (NAFLD) |
| title_full | Effect of water extract of bay laurel (Laurus nobilis L.) on non-alcoholic fatty liver disease (NAFLD) |
| title_fullStr | Effect of water extract of bay laurel (Laurus nobilis L.) on non-alcoholic fatty liver disease (NAFLD) |
| title_full_unstemmed | Effect of water extract of bay laurel (Laurus nobilis L.) on non-alcoholic fatty liver disease (NAFLD) |
| title_short | Effect of water extract of bay laurel (Laurus nobilis L.) on non-alcoholic fatty liver disease (NAFLD) |
| title_sort | effect of water extract of bay laurel laurus nobilis l on non alcoholic fatty liver disease nafld |
| topic | nafld bay laurel leaves lipid accumulation inflammation apoptosis |
| url | https://foodandnutritionresearch.net/index.php/fnr/article/view/10668/19392 |
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