Staphylococcal Cassette Chromosome mec, Evolution and Genetic Lines of Methicillin Resistant Staphylococcus aureus
Methicillin resistant Staphylococcus aureus (MRSA) is the main pathogen of hospital- and community-associated infections. Methicillin resistance is due to mecA gene located in a mobile complex element, staphylococcal cassette chromosome mec (SCCmec). The structure of the staphylococcal cassettes is...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/456 |
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| author | V. V. Gostev S. V. Sidorenko |
| author_facet | V. V. Gostev S. V. Sidorenko |
| author_sort | V. V. Gostev |
| collection | DOAJ |
| description | Methicillin resistant Staphylococcus aureus (MRSA) is the main pathogen of hospital- and community-associated infections. Methicillin resistance is due to mecA gene located in a mobile complex element, staphylococcal cassette chromosome mec (SCCmec). The structure of the staphylococcal cassettes is diverse. At present eleven types of the cassettes are described. Types I-IV SCCmec are always associated with epidemiologically significant genetic lines of Staphylococcus. Thus, the pandemic hospital-associated MRSA (HA MRSA) belonging to CC5 and CC8 are of the types I-III SCCmec. The prevalence of virulent community-associated MRSA (CA MRSA) in many regions of the world is first of all connected with the characteristics of the type IV SCCmec structure and the presence of a recently described arginine catabolic mobile element (ACME) increasing the colonization activity of Staphylococcus. The review presents the up-to-date data on the origin, genetic structure and classification of SCCmec. Global genetic lines of MRSA are described and the problem of CA MRSA is discussed. |
| format | Article |
| id | doaj-art-9765de02315044f7af7c2a2ecbb2eb8f |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-9765de02315044f7af7c2a2ecbb2eb8f2025-08-20T03:20:37ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01579-103846455Staphylococcal Cassette Chromosome mec, Evolution and Genetic Lines of Methicillin Resistant Staphylococcus aureusV. V. Gostev0S. V. Sidorenko1Research Institute of Children's InfectionsResearch Institute of Children's InfectionsMethicillin resistant Staphylococcus aureus (MRSA) is the main pathogen of hospital- and community-associated infections. Methicillin resistance is due to mecA gene located in a mobile complex element, staphylococcal cassette chromosome mec (SCCmec). The structure of the staphylococcal cassettes is diverse. At present eleven types of the cassettes are described. Types I-IV SCCmec are always associated with epidemiologically significant genetic lines of Staphylococcus. Thus, the pandemic hospital-associated MRSA (HA MRSA) belonging to CC5 and CC8 are of the types I-III SCCmec. The prevalence of virulent community-associated MRSA (CA MRSA) in many regions of the world is first of all connected with the characteristics of the type IV SCCmec structure and the presence of a recently described arginine catabolic mobile element (ACME) increasing the colonization activity of Staphylococcus. The review presents the up-to-date data on the origin, genetic structure and classification of SCCmec. Global genetic lines of MRSA are described and the problem of CA MRSA is discussed.https://www.antibiotics-chemotherapy.ru/jour/article/view/456sccmecmethicillin resistant staphylococcus aureussccmec |
| spellingShingle | V. V. Gostev S. V. Sidorenko Staphylococcal Cassette Chromosome mec, Evolution and Genetic Lines of Methicillin Resistant Staphylococcus aureus Антибиотики и Химиотерапия sccmec methicillin resistant staphylococcus aureus sccmec |
| title | Staphylococcal Cassette Chromosome mec, Evolution and Genetic Lines of Methicillin Resistant Staphylococcus aureus |
| title_full | Staphylococcal Cassette Chromosome mec, Evolution and Genetic Lines of Methicillin Resistant Staphylococcus aureus |
| title_fullStr | Staphylococcal Cassette Chromosome mec, Evolution and Genetic Lines of Methicillin Resistant Staphylococcus aureus |
| title_full_unstemmed | Staphylococcal Cassette Chromosome mec, Evolution and Genetic Lines of Methicillin Resistant Staphylococcus aureus |
| title_short | Staphylococcal Cassette Chromosome mec, Evolution and Genetic Lines of Methicillin Resistant Staphylococcus aureus |
| title_sort | staphylococcal cassette chromosome mec evolution and genetic lines of methicillin resistant staphylococcus aureus |
| topic | sccmec methicillin resistant staphylococcus aureus sccmec |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/456 |
| work_keys_str_mv | AT vvgostev staphylococcalcassettechromosomemecevolutionandgeneticlinesofmethicillinresistantstaphylococcusaureus AT svsidorenko staphylococcalcassettechromosomemecevolutionandgeneticlinesofmethicillinresistantstaphylococcusaureus |