Severe interstitial lung disease risk prediction in anti-melanoma differentiation-associated protein 5 positive dermatomyositis: the STRAD-Ro52 model
Objective Anti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated interstitial lung disease (MDA5+DM-ILD) often leads to acute respiratory failure and endangers lives. This study quantitatively analysed chest high-resolution computed tomography (HRCT) images to assess MDA...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2440621 |
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| author | Fei Xiao Feilong Chen DongSheng Li Songyuan Zheng Xiao Liang Juan Wu JunYuan Zhong Xiangliang Tan Rui Chen Junqing Zhu Shixian Chen Juan Li |
| author_facet | Fei Xiao Feilong Chen DongSheng Li Songyuan Zheng Xiao Liang Juan Wu JunYuan Zhong Xiangliang Tan Rui Chen Junqing Zhu Shixian Chen Juan Li |
| author_sort | Fei Xiao |
| collection | DOAJ |
| description | Objective Anti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated interstitial lung disease (MDA5+DM-ILD) often leads to acute respiratory failure and endangers lives. This study quantitatively analysed chest high-resolution computed tomography (HRCT) images to assess MDA5+DM-ILD and establish a risk prediction model for severe ILD within six months.Methods We developed a ‘Standardized Threshold Ratio Analysis & Distribution’ (STRAD) to analyse lung HRCT images. In this retrospective study, 51 patients with MDA5+DM-ILD were included and divided into severe-ILD and non-severe-ILD groups based on the occurrence of acute respiratory failure within six months post-diagnosis of MDA5+DM. The STRAD parameters, clinical indicators and treatments were compared between the two groups. Least absolute shrinkage and selection operator (LASSO) regression was used to select the optimal STRAD parameters. Multivariate analysis selected clinical factors to be further combined with STRAD to enhance the predictive performance of the final model (STRAD-Ro52 model).Results Significant differences were observed between the two groups in STRAD parameters, anti-Ro52 antibody titers, presence of anti-Ro52 antibodies, age, ESR, ALB, Pa/FiO2, IgM and IL-4 levels. The STRAD parameters were significantly correlated with demographic, inflammatory, organ function and immunological indicators. Lasso logistic regression analysis identified the −699 to −650 HU lung tissue proportion (%V7) as the optimal parameter for predicting severe ILD and S6·%V7, and the distribution of %V7 in the mid lungs was the optimal space parameter. Multifactorial regression of clinical indicators showed that the presence of anti-Ro52 antibodies was an independent risk factor for severe ILD, leading to the establishment of the STRAD-Ro52 model.Conclusions The STRAD-Ro52 model assists in identifying MDA5+DM patients at risk of developing severe ILD within six months, further optimizing precise disease management and clinical research design. |
| format | Article |
| id | doaj-art-975bc541b5564a3b808917cd2c15b037 |
| institution | DOAJ |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-975bc541b5564a3b808917cd2c15b0372025-08-20T02:40:03ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2024.2440621Severe interstitial lung disease risk prediction in anti-melanoma differentiation-associated protein 5 positive dermatomyositis: the STRAD-Ro52 modelFei Xiao0Feilong Chen1DongSheng Li2Songyuan Zheng3Xiao Liang4Juan Wu5JunYuan Zhong6Xiangliang Tan7Rui Chen8Junqing Zhu9Shixian Chen10Juan Li11Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaSouthern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Rheumatology and Immunology, People’s Hospital of Ganzhou City, Ganzhou, ChinaDepartment of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Rheumatology and Immunology, People’s Hospital of Ganzhou City, Ganzhou, ChinaDepartment of Medical Imaging, People’s Hospital of Ganzhou City, Ganzhou, ChinaDepartment of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Biology, School of Life and Health, Hainan University, Haikou, ChinaDepartment of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaObjective Anti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated interstitial lung disease (MDA5+DM-ILD) often leads to acute respiratory failure and endangers lives. This study quantitatively analysed chest high-resolution computed tomography (HRCT) images to assess MDA5+DM-ILD and establish a risk prediction model for severe ILD within six months.Methods We developed a ‘Standardized Threshold Ratio Analysis & Distribution’ (STRAD) to analyse lung HRCT images. In this retrospective study, 51 patients with MDA5+DM-ILD were included and divided into severe-ILD and non-severe-ILD groups based on the occurrence of acute respiratory failure within six months post-diagnosis of MDA5+DM. The STRAD parameters, clinical indicators and treatments were compared between the two groups. Least absolute shrinkage and selection operator (LASSO) regression was used to select the optimal STRAD parameters. Multivariate analysis selected clinical factors to be further combined with STRAD to enhance the predictive performance of the final model (STRAD-Ro52 model).Results Significant differences were observed between the two groups in STRAD parameters, anti-Ro52 antibody titers, presence of anti-Ro52 antibodies, age, ESR, ALB, Pa/FiO2, IgM and IL-4 levels. The STRAD parameters were significantly correlated with demographic, inflammatory, organ function and immunological indicators. Lasso logistic regression analysis identified the −699 to −650 HU lung tissue proportion (%V7) as the optimal parameter for predicting severe ILD and S6·%V7, and the distribution of %V7 in the mid lungs was the optimal space parameter. Multifactorial regression of clinical indicators showed that the presence of anti-Ro52 antibodies was an independent risk factor for severe ILD, leading to the establishment of the STRAD-Ro52 model.Conclusions The STRAD-Ro52 model assists in identifying MDA5+DM patients at risk of developing severe ILD within six months, further optimizing precise disease management and clinical research design.https://www.tandfonline.com/doi/10.1080/07853890.2024.2440621Dermatomyositisanti-melanoma differentiation-associated protein 5 antibodysevere interstitial lung diseasecomputed tomographyrisk modelStandardized Threshold Ratio Analysis & Distribution |
| spellingShingle | Fei Xiao Feilong Chen DongSheng Li Songyuan Zheng Xiao Liang Juan Wu JunYuan Zhong Xiangliang Tan Rui Chen Junqing Zhu Shixian Chen Juan Li Severe interstitial lung disease risk prediction in anti-melanoma differentiation-associated protein 5 positive dermatomyositis: the STRAD-Ro52 model Annals of Medicine Dermatomyositis anti-melanoma differentiation-associated protein 5 antibody severe interstitial lung disease computed tomography risk model Standardized Threshold Ratio Analysis & Distribution |
| title | Severe interstitial lung disease risk prediction in anti-melanoma differentiation-associated protein 5 positive dermatomyositis: the STRAD-Ro52 model |
| title_full | Severe interstitial lung disease risk prediction in anti-melanoma differentiation-associated protein 5 positive dermatomyositis: the STRAD-Ro52 model |
| title_fullStr | Severe interstitial lung disease risk prediction in anti-melanoma differentiation-associated protein 5 positive dermatomyositis: the STRAD-Ro52 model |
| title_full_unstemmed | Severe interstitial lung disease risk prediction in anti-melanoma differentiation-associated protein 5 positive dermatomyositis: the STRAD-Ro52 model |
| title_short | Severe interstitial lung disease risk prediction in anti-melanoma differentiation-associated protein 5 positive dermatomyositis: the STRAD-Ro52 model |
| title_sort | severe interstitial lung disease risk prediction in anti melanoma differentiation associated protein 5 positive dermatomyositis the strad ro52 model |
| topic | Dermatomyositis anti-melanoma differentiation-associated protein 5 antibody severe interstitial lung disease computed tomography risk model Standardized Threshold Ratio Analysis & Distribution |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2440621 |
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