Cerebellar Development and Plasticity: Perspectives for Motor Coordination Strategies, for Motor Skills, and for Therapy
The role of the mammalian cerebellum ranges from motor coordination, sensory-motor integration, motor learning, and timing to nonmotor functions such as cognition. In terms of motor function, the development of the cerebellum is of particular interest because animal studies show that the development...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2005.153 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559157742403584 |
|---|---|
| author | J. D. Swinny J. J. L. van der Want A. Gramsbergen |
| author_facet | J. D. Swinny J. J. L. van der Want A. Gramsbergen |
| author_sort | J. D. Swinny |
| collection | DOAJ |
| description | The role of the mammalian cerebellum ranges from motor coordination, sensory-motor integration, motor learning, and timing to nonmotor functions such as cognition. In terms of motor function, the development of the cerebellum is of particular interest because animal studies show that the development of the cerebellar cortical circuitry closely parallels motor coordination. Ultrastructural analysis of the morphological development of the cerebellar circuitry, coupled with the temporal and spatial identification of the neurochemical substrates expressed during development, will help to elucidate their roles in the establishment of the cerebellar circuitry and hence motor activity. Furthermore, the convenience of a number of naturally occurring mouse mutations has allowed a functional dissection of the various cellular elements that make up the cerebellar circuitry. This understanding will also help in the approach to possible therapies of pathologies arising during development because tile cerebellum is especially prone to such perturbation because of its late development. |
| format | Article |
| id | doaj-art-975b9216a0ee474cb6500068e03b6a1a |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-975b9216a0ee474cb6500068e03b6a1a2025-02-03T01:30:45ZengWileyNeural Plasticity2090-59041687-54432005-01-01122-315316010.1155/NP.2005.153Cerebellar Development and Plasticity: Perspectives for Motor Coordination Strategies, for Motor Skills, and for TherapyJ. D. Swinny0J. J. L. van der Want1A. Gramsbergen2Laboratory for Stress Neurobiology, 409 Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia 19104, PA, USALaboratory for Cell Biology and Electron Microscopy, University Medical Center Groningen, The NetherlandsLaboratory for Medical Physiology, University Medical Center Groningen, The NetherlandsThe role of the mammalian cerebellum ranges from motor coordination, sensory-motor integration, motor learning, and timing to nonmotor functions such as cognition. In terms of motor function, the development of the cerebellum is of particular interest because animal studies show that the development of the cerebellar cortical circuitry closely parallels motor coordination. Ultrastructural analysis of the morphological development of the cerebellar circuitry, coupled with the temporal and spatial identification of the neurochemical substrates expressed during development, will help to elucidate their roles in the establishment of the cerebellar circuitry and hence motor activity. Furthermore, the convenience of a number of naturally occurring mouse mutations has allowed a functional dissection of the various cellular elements that make up the cerebellar circuitry. This understanding will also help in the approach to possible therapies of pathologies arising during development because tile cerebellum is especially prone to such perturbation because of its late development.http://dx.doi.org/10.1155/NP.2005.153 |
| spellingShingle | J. D. Swinny J. J. L. van der Want A. Gramsbergen Cerebellar Development and Plasticity: Perspectives for Motor Coordination Strategies, for Motor Skills, and for Therapy Neural Plasticity |
| title | Cerebellar Development and Plasticity: Perspectives for Motor Coordination Strategies, for Motor Skills, and for Therapy |
| title_full | Cerebellar Development and Plasticity: Perspectives for Motor Coordination Strategies, for Motor Skills, and for Therapy |
| title_fullStr | Cerebellar Development and Plasticity: Perspectives for Motor Coordination Strategies, for Motor Skills, and for Therapy |
| title_full_unstemmed | Cerebellar Development and Plasticity: Perspectives for Motor Coordination Strategies, for Motor Skills, and for Therapy |
| title_short | Cerebellar Development and Plasticity: Perspectives for Motor Coordination Strategies, for Motor Skills, and for Therapy |
| title_sort | cerebellar development and plasticity perspectives for motor coordination strategies for motor skills and for therapy |
| url | http://dx.doi.org/10.1155/NP.2005.153 |
| work_keys_str_mv | AT jdswinny cerebellardevelopmentandplasticityperspectivesformotorcoordinationstrategiesformotorskillsandfortherapy AT jjlvanderwant cerebellardevelopmentandplasticityperspectivesformotorcoordinationstrategiesformotorskillsandfortherapy AT agramsbergen cerebellardevelopmentandplasticityperspectivesformotorcoordinationstrategiesformotorskillsandfortherapy |