Enhanced Osteogenesis and Antibacterial Properties of Ketoprofen-Loaded MgCu-MOF74-Coated Titanium Alloy for Bone Implant
To address the dual clinical challenges of poor osseointegration and inadequate analgesia caused by postoperative infections in traditional titanium implants, this study proposes a multifunctional synergistic strategy based on metal—organic frameworks (MOFs). By integrating drug-controlled release a...
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MDPI AG
2025-06-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/16/6/222 |
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| author | Ziqing Duan Yifeng Yao Jiamin Liu Yanni Tan Qingge Wang Man Fang Aqsa Kanwal Shuqiao Cheng Juan Huang Hong Wu |
| author_facet | Ziqing Duan Yifeng Yao Jiamin Liu Yanni Tan Qingge Wang Man Fang Aqsa Kanwal Shuqiao Cheng Juan Huang Hong Wu |
| author_sort | Ziqing Duan |
| collection | DOAJ |
| description | To address the dual clinical challenges of poor osseointegration and inadequate analgesia caused by postoperative infections in traditional titanium implants, this study proposes a multifunctional synergistic strategy based on metal—organic frameworks (MOFs). By integrating drug-controlled release and ionic microenvironment regulation, it constructs a titanium-based implant coating system with antibacterial and bone-regenerative properties. Ketoprofen, a drug with excellent analgesic properties, was loaded into MgCu-MOF74 powder, and the Ket@MgCu-MOF74 powder was successfully anchored onto the surface of the titanium alloy through dopamine-mediated adhesion. The maximum load of ketoprofen to MgCu-MOF74 is 18.55%, and it has a good controllable release effect. The results showed that MgCu-MOF74/Ti and Ket@MgCu-MOF74/Ti coatings enhanced osteogenic performance by promoting alkaline phosphatase activity, collagen secretion, and extracellular matrix mineralization. Additionally, the release of Mg<sup>2+</sup> and Cu<sup>2+</sup> created an alkaline environment, providing antibacterial properties. In summary, the MOF enabled the controlled release of ketoprofen, and the composite coating can improve osteogenic differentiation of osteoblasts and enhance the antibacterial properties of titanium alloy implants. |
| format | Article |
| id | doaj-art-97586b3f02b2407aaf791fa05ef5dcfc |
| institution | Kabale University |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-97586b3f02b2407aaf791fa05ef5dcfc2025-08-20T03:24:36ZengMDPI AGJournal of Functional Biomaterials2079-49832025-06-0116622210.3390/jfb16060222Enhanced Osteogenesis and Antibacterial Properties of Ketoprofen-Loaded MgCu-MOF74-Coated Titanium Alloy for Bone ImplantZiqing Duan0Yifeng Yao1Jiamin Liu2Yanni Tan3Qingge Wang4Man Fang5Aqsa Kanwal6Shuqiao Cheng7Juan Huang8Hong Wu9State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Breast Surgery, Xiangya Hospital, Central South University, Changsha 410008, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, ChinaTo address the dual clinical challenges of poor osseointegration and inadequate analgesia caused by postoperative infections in traditional titanium implants, this study proposes a multifunctional synergistic strategy based on metal—organic frameworks (MOFs). By integrating drug-controlled release and ionic microenvironment regulation, it constructs a titanium-based implant coating system with antibacterial and bone-regenerative properties. Ketoprofen, a drug with excellent analgesic properties, was loaded into MgCu-MOF74 powder, and the Ket@MgCu-MOF74 powder was successfully anchored onto the surface of the titanium alloy through dopamine-mediated adhesion. The maximum load of ketoprofen to MgCu-MOF74 is 18.55%, and it has a good controllable release effect. The results showed that MgCu-MOF74/Ti and Ket@MgCu-MOF74/Ti coatings enhanced osteogenic performance by promoting alkaline phosphatase activity, collagen secretion, and extracellular matrix mineralization. Additionally, the release of Mg<sup>2+</sup> and Cu<sup>2+</sup> created an alkaline environment, providing antibacterial properties. In summary, the MOF enabled the controlled release of ketoprofen, and the composite coating can improve osteogenic differentiation of osteoblasts and enhance the antibacterial properties of titanium alloy implants.https://www.mdpi.com/2079-4983/16/6/222titanium alloymetal–organic frameworksurface modificationantibacterial propertyosseointegration |
| spellingShingle | Ziqing Duan Yifeng Yao Jiamin Liu Yanni Tan Qingge Wang Man Fang Aqsa Kanwal Shuqiao Cheng Juan Huang Hong Wu Enhanced Osteogenesis and Antibacterial Properties of Ketoprofen-Loaded MgCu-MOF74-Coated Titanium Alloy for Bone Implant Journal of Functional Biomaterials titanium alloy metal–organic framework surface modification antibacterial property osseointegration |
| title | Enhanced Osteogenesis and Antibacterial Properties of Ketoprofen-Loaded MgCu-MOF74-Coated Titanium Alloy for Bone Implant |
| title_full | Enhanced Osteogenesis and Antibacterial Properties of Ketoprofen-Loaded MgCu-MOF74-Coated Titanium Alloy for Bone Implant |
| title_fullStr | Enhanced Osteogenesis and Antibacterial Properties of Ketoprofen-Loaded MgCu-MOF74-Coated Titanium Alloy for Bone Implant |
| title_full_unstemmed | Enhanced Osteogenesis and Antibacterial Properties of Ketoprofen-Loaded MgCu-MOF74-Coated Titanium Alloy for Bone Implant |
| title_short | Enhanced Osteogenesis and Antibacterial Properties of Ketoprofen-Loaded MgCu-MOF74-Coated Titanium Alloy for Bone Implant |
| title_sort | enhanced osteogenesis and antibacterial properties of ketoprofen loaded mgcu mof74 coated titanium alloy for bone implant |
| topic | titanium alloy metal–organic framework surface modification antibacterial property osseointegration |
| url | https://www.mdpi.com/2079-4983/16/6/222 |
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